ArticleAngewandte Chemie (International ed. in English)2020
Enzyme-Instructed Assemblies Enable Mitochondria Localization of Histone H2B in Cancer Cells.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation.Nature communications · 2025Article
- Precise Regulations at the Subcellular Level through Intracellular Polymerization, Assembly, and Transformation.JACS Au · 2024Review
- Peptide Self-Assembly Facilitating DNA Transfection and the Application in Inhibiting Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
- Multistage Self-Assembled Nanomaterials for Cancer Immunotherapy.Molecules (Basel, Switzerland) · 2023Review
- Engineering of antimicrobial peptide fibrils with feedback degradation of bacterial-secreted enzymes.Chemical science · 2023Article
- Peptide Assemblies for Cancer Therapy.ChemMedChem · 2023Review
- Prospects of Using Protein Engineering for Selective Drug Delivery into a Specific Compartment of Target Cells.Pharmaceutics · 2023Review
- Enzyme-instructed morphology transformation of mitochondria-targeting peptide for the selective eradication of osteosarcoma.RSC chemical biology · 2022Article
- Designing bioresponsive nanomaterials for intracellular self-assembly.Nature reviews. Chemistry · 2022Review
- Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications.Chemical communications (Cambridge, England) · 2021Review
- Enzymatic Delivery of Magnetic Nanoparticles into Mitochondria of Live Cells.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2021Article
- Biological functions of supramolecular assemblies of small molecules in cellular environment.RSC chemical biology · 2021Article
- pH-Responsive Self-Assembly of Designer Aromatic Peptide Amphiphiles and Enzymatic Post-Modification of Assembled Structures.International journal of molecular sciences · 2021Article
- Peptide Assemblies Mimicking Chaperones for Protein Trafficking.Bioconjugate chemistry · 2021Article
- Evolution of Supramolecular Systems Towards Next-Generation Biosensors.Frontiers in chemistry · 2021Review
- Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials.Frontiers in bioengineering and biotechnology · 2021Review
- Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells.Cell reports. Physical science · 2020Article
- Enzymatic Noncovalent Synthesis.Chemical reviews · 2020Review
- Enzyme-Instructed Self-Assembly for Subcellular Targeting.ACS omega · 2020Review
- Biomaterials based on noncovalent interactions of small molecules.EXCLI journal · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Presently, little is known of how the inter-organelle crosstalk impacts cancer cells owing to the lack of approaches that can manipulate inter-organelle communication in cancer cells. We found that a negatively charged, enzyme cleavable peptide (MitoFlag) enables the trafficking of histone protein H2B, a nuclear protein, to the mitochondria in cancer cells. MitoFlag interacts with the nuclear location sequence of H2B to block it from entering the nucleus. A protease on the mitochondria cleaves the Flag from the MitoFlag/H2B complex to form assemblies that retain H2B on the mitochondria and facilitate H2B entering the mitochondria. Adding NLS, replacing aspartic acid by glutamic acid residues, or changing the l- to d-aspartic acid residue on MitoFlag abolishes the trafficking of H2B into mitochondria of HeLa cells. As the first example of the enzyme-instructed self-assembly of a synthetic peptide for trafficking endogenous proteins, this work provides insights for understanding and manipulating inter-organelle communication in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.