Evidence map›Paper›PMID 32119694›Full record

ArticlePloS one2020

Impact of epicardial adipose tissue volume upon left ventricular dysfunction in patients with mild-to-moderate aortic stenosis: A post-hoc analysis.

F Hardt, M Becker, V Brandenburg, J Grebe, T Dirrichs, R F Gohmann, K Fehrenbacher, J Schmoee, S D Reinartz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

F HardtDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0003-1562-0205
M BeckerDepartment of Cardiology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
V BrandenburgDepartment of Cardiology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
J GrebeDepartment of Cardiology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
T DirrichsDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
R F GohmannDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
K FehrenbacherDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
J SchmoeeDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
S D ReinartzDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic stenosis (AS) may lead to diastolic dysfunction and later on heart failure (HF) with preserved left ventricular ejection fraction (HFpEF) via increased afterload and left-ventricular (LV) hypertrophy. Since epicardial adipose tissue (EAT) is a metabolically active fat depot that is adjacent to the myocardium and can influence cardiomyocytes and LV function via secretion of proinflammatory cytokines, we hypothesized that high amounts of EAT, as assessed by computed tomography (CT), may aggravate the development and severity of LV hypertrophy and diastolic dysfunction in the context of AS.

methodsWe studied 50 patients (mean age 71 ± 9 years; 9 women) in this preliminary study with mild or moderate AS and mild to severe LV diastolic dysfunction (LVDD), diagnosed by echocardiography, who underwent non-contrast cardiac CT and echocardiography. EAT parameters were measured on 2nd generation dual source CT. Conventional two-dimensional echocardiography and Tissue Doppler Imaging (TDI) was performed to assess LV function and to derive myocardial straining parameter. All patients had a preserved LV ejection fraction > 50%. Data was analysed using Pearson's correlation.

resultsOnly weak correlation was found between EAT volume or density and E/é ratio as LVDD marker (r = -.113 p = .433 and r = .260, p = .068 respectively). Also, EAT volume or density were independent from Global Strain Parameters (r = 0.058 p = .688 and r = -0.207 p = .239). E/é ratio was strongly associated with LVDD (r = .761 p≤0.0001) and Strain Parameters were moderately associated with LV Ejection Fraction (r = -.669 p≤0.001 and r = -.454 P≤0.005).

conclusionsIn this preliminary study in patients with AS, the EAT volume and density as assessed by CT correlated only weakly with LVDD, as expressed by the commonly used E/é ratio, and with LV strain function. Hence, measuring EAT volume and density may neither contribute to the prediction nor upon the severity of LVDD, respectively.

Indexed as

Adipose TissueAdiposityAgedAged, 80 and overAortic Valve StenosisDiastoleEchocardiographyFemaleHeart FailureHumansHypertrophy, Left VentricularMaleMiddle AgedPericardiumStroke VolumeTomography, X-Ray Computed

Identifiers

PMID32119694
PMCPMC7051069
OpenAlexW3007159871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.