ArticlePLoS neglected tropical diseases2020
Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Insight into the genetic diversity ofMicrobiology spectrum · 2026Article
- Whole-genome sequencing reveals genetic diversity and transmission dynamics ofMicrobial genomics · 2026Article
- Detection of Mycobacteria in Arabian camels and antimycobacterial potential of Moringa oleifera.Scientific reports · 2025Article
- Article
- Review
- Molecular Characterisation ofCurrent issues in molecular biology · 2023Article
- Article
- Zoonotic Tuberculosis: A Neglected Disease in the Middle East and North Africa (MENA) Region.Diseases (Basel, Switzerland) · 2023Review
- Evaluating Data Sharing of SARS-CoV-2 Genomes for Molecular Epidemiology across the COVID-19 Pandemic.Viruses · 2023Article
- Ancient pathogens provide a window into health and well-being.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Whole genome sequencing of EthiopianFrontiers in microbiology · 2023Article
- Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals.Microorganisms · 2022Review
- Phylogeography of Sub-Saharan Mitochondrial Lineages Outside Africa Highlights the Roles of the Holocene Climate Changes and the Atlantic Slave Trade.International journal of molecular sciences · 2022Article
- Article
- The source and fate of Mycobacterium tuberculosis complex in wastewater and possible routes of transmission.BMC public health · 2022Article
- Temporal trends and prediction of bovine tuberculosis: a time series analysis in the North-East of Iran.Iranian journal of veterinary research · 2022Article
- Whole-Genome SNP Analysis Identifies PutativeMicroorganisms · 2021Article
- An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
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9 authors.
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Abstract
Mycobacterium bovis is the pathogenic agent responsible for bovine tuberculosis (bTB), a zoonotic disease affecting mostly cattle, but also transmittable to humans and wildlife. Genetic studies on M. bovis allow to detect possible routes of bTB transmission and the identification of genetic reservoirs that may provide an essential framework for public health action. We used a database with 1235 M. bovis genotypes collected from different regions in Africa with 45 new Mozambican samples. Our analyses, based on phylogeographic and population genetics' approaches, allowed to identify two clear trends. First, the genetic diversity of M. bovis is geographically clustered across the continent, with the only incidences of long-distance sharing of genotypes, between South Africa and Algeria, likely due to recent European introductions. Second, there is a broad gradient of diversity from Northern to Southern Africa with a diversity focus on the proximity to the Near East, where M. bovis likely emerged with animal domestication in the last 10,000 years. Diversity indices are higher in Eastern Africa, followed successively by Northern, Central, Southern and Western Africa, roughly correlating with the regional archaeological records of introduction of animal domesticates. Given this scenario M. bovis in Africa was probably established millennia ago following a concomitant spread with cattle, sheep and goat. Such scenario could translate into long-term locally adapted lineages across Africa. This work describes a novel scenario for the spread of M. bovis in Africa using the available genetic data, opening the field to further studies using higher resolution genomic data.
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