Evidence map›Paper›PMID 32119511›Full record

ArticleACS chemical biology2020

Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.

Daniel H Ramirez, Chanat Aonbangkhen, Hung-Yi Wu, Jeffrey A Naftaly, Stephanie Tang, Timothy R O'Meara, Christina M Woo

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Induced proximity-based therapeutic modalities.Nature reviews. Drug discovery · 2026
    Review
  8. A Scalable Design for Proximity-Inducing Molecules.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. O-GlcNAc informatics: advances and trends.Analytical and bioanalytical chemistry · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel H RamirezDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-3288-9951
Chanat AonbangkhenDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0002-7378-1341
Hung-Yi WuDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Jeffrey A NaftalyDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Stephanie TangDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0002-2705-2201
Timothy R O'MearaDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Christina M WooDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-8687-9105
Harvard University · US

Funding

Tools to facilitate manipulation of protein-specific glycosylation stoichiometry in cellsU01CA242098 · NCI · HARVARD UNIVERSITY · PI WOO, CHRISTINA · 2019 to 2021
$1.4M
NCI NIH HHS U01 CA242098
6 · The paper itself

Abstract

O-Linked

Indexed as

alpha-SynucleinGlycosylationHEK293 CellsHumansN-AcetylglucosaminyltransferasesProtein EngineeringProtein Processing, Post-TranslationalProteomeRecombinant Fusion ProteinsSingle-Domain Antibodiesalpha-SynucleinN-AcetylglucosaminyltransferasesO-GlcNAc transferaseProteomeRecombinant Fusion ProteinsSingle-Domain AntibodiesSNCA protein, human

Identifiers

PMID32119511
PMCPMC7296736
OpenAlexW3009287579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.