ArticleThe journal of physical chemistry. B2020
Simple Calculation of Phase Diagrams for Liquid-Liquid Phase Separation in Solutions of Two Macromolecular Solute Species.
Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Automated navigation of condensate phase behavior with active machine learning.Nature communications · 2025Article
- Article
- Crowder titrations enable the quantification of driving forces for macromolecular phase separation.Biophysical journal · 2024Article
- Phase Separation in Complex Mixtures with Many Components: Analytical Expressions for Spinodal Manifolds.ACS omega · 2024Article
- Macromolecular Crowding, Phase Separation, and Homeostasis in the Orchestration of Bacterial Cellular Functions.Chemical reviews · 2024Review
- Self-Lubricating and Shape-Stable Phase-Change Materials Based on Epoxy Resin and Vegetable Oils.Polymers · 2023Article
- Thermodynamically controlled multiphase separation of heterogeneous liquid crystal colloids.Nature communications · 2023Article
- Article
- Phase Transitions of Associative Biomacromolecules.Chemical reviews · 2023Review
- Developments in describing equilibrium phase transitions of multivalent associative macromolecules.Current opinion in structural biology · 2023Review
- The stoichiometric interaction model for mesoscopic MD simulations of liquid-liquid phase separation.Biophysical journal · 2022Article
- Polyphenol-solubility alters amyloid fibril formation of α-synuclein.Protein science : a publication of the Protein Society · 2021Article
- Phase-Separating Binary Polymer Mixtures: The Degeneracy of the Virial Coefficients and Their Extraction from Phase Diagrams.ACS omega · 2021Article
- Breakdown of supersaturation barrier links protein folding to amyloid formation.Communications biology · 2021Article
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Abstract
A simple method is described for the calculation of two- and three-dimensional phase diagrams describing stability and coexistence curves or surfaces separating one- and two-phase regions in composition/temperature space of a solution containing solute species 1 and 2. The calculation requires a quantitative description of the intermolecular potentials of mean force acting between like (1-1 and 2-2) and unlike (1-2) species. Example calculations are carried out for solutions of species interacting via spherically symmetric square-well potentials as first-order models for protein-protein interaction. When the interaction between species 1 and 2 is more repulsive than those acting between like species, the two-phase region is characterized by an equilibrium between a phase enriched in 1 and depleted in 2 and a phase enriched in 2 and depleted in 1. When the interaction between species 1 and 2 is more attractive than those acting between like species, the two-phase region is characterized by an equilibrium between a phase enriched in both species and a phase depleted in both species. The latter example provides a first-order description of coacervate formation without postulating specific interactions between the two solute species.
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