Evidence map›Paper›PMID 32118419›Full record

ArticleJournal of the American Chemical Society2020

A Selenourea-Thiourea Brønsted Acid Catalyst Facilitates Asymmetric Conjugate Additions of Amines to α,β-Unsaturated Esters.

Yingfu Lin, William J Hirschi, Anuj Kunadia, Anirudra Paul, Ion Ghiviriga, Khalil A Abboud, Rachael W Karugu, Mathew J Vetticatt, Jennifer S Hirschi, Daniel Seidel

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingfu LinCenter for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
William J HirschiDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.
Anuj KunadiaDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Anirudra PaulCenter for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Ion GhivirigaCenter for NMR Spectroscopy, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Khalil A AbboudCenter for X-ray Crystallography, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Rachael W KaruguDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.
Mathew J VetticattDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.ORCID 0000-0001-5709-0885
Jennifer S HirschiDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.
Daniel SeidelCenter for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0001-6725-111X

Funding

Novel Concepts and Mechanistic Probes in CatalysisR01GM126283 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI VETTICATT, MATHEW J · 2018 to 2022
$1.5M
NIGMS NIH HHS R01 GM126283
6 · The paper itself

Abstract

β-Amino esters are obtained with high levels of enantioselectivity via the conjugate addition of cyclic amines to unactivated α,β-unsaturated esters. A related strategy enables the kinetic resolution of racemic cyclic 2-arylamines, using benzyl acrylate as the resolving agent. Reactions are facilitated by an unprecedented selenourea-thiourea organocatalyst. As elucidated by DFT calculations and

Indexed as

AminesCatalysisDensity Functional TheoryEstersKineticsModels, ChemicalOrganoselenium CompoundsThioureaUreaAminesEstersOrganoselenium CompoundsselenoureaThioureaUrea

Identifiers

PMID32118419
PMCPMC7533150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.