Evidence map›Paper›PMID 32118318›Full record

ArticleJournal of clinical laboratory analysis2020

Diagnostic and prognostic values of anti-helicobacter pylori antibody combined with serum CA724, CA19-9, and CEA for young patients with early gastric cancer.

Xuyang Gong, Heng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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  18. Blood index panel for gastric cancer detection.World journal of gastrointestinal surgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xuyang GongDepartment of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Heng ZhangDepartment of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0001-7091-7496
Central Hospital of Wuhan · CN

Funding

Clinical medical research project of Wuhan health bureau WX12B09
6 · The paper itself

Abstract

backgroundTo investigate the value of anti-helicobacter pylori (Hp) antibody, serum carbohydrate antigen (CA)-724, CA19-9, and carcinoembryonic antigen (CEA) in the diagnosis and prognosis evaluation of young patients with early gastric cancer.

methodsA total of 200 young patients with gastric cancer from April 2014 to December 2015 were enrolled. A total of 206 patients with gastritis and 204 healthy subjects were also selected. Gastric cancer patients were followed up for 3 years, and the number of recurrences, metastasis, and death was recorded.

resultsThe positive rate of anti-Hp antibody, CA724, CA19-9, and CEA in young patients with early gastric cancer were significantly higher than those in gastritis and healthy subjects (P < .05), and was positively correlated with tumor stage, tumor size, and lymph node metastasis (P < .05). The predicting model was as follows: Logit (P) = 26.433-3.014(CA724)-3.908(CA19-9)-0.303(CEA)-2.208(anti-Hp antibody, Positive = 1; Negative = 0). This model had a high value in identifying young patients with early gastric cancer with AUC of 0.918, and the estimated probability was .806. Compared to patients with negative anti-Hp antibody and low serum levels of CA724, CA19-9, and CEA, the recurrence rate, metastasis rate, and mortality of patients with positive anti-Hp antibody, high serum levels of CA724, CA19-9, and CEA increased significantly (P < .05).

conclusionThis study indicated that anti-Hp antibody combined with CA724, CA19-9, and CEA had important value in the identification of young patients with early gastric cancer and were of great value in evaluating the risk of postoperative recurrence, metastasis, and death.

Indexed as

AdultAntibodies, BacterialAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenCase-Control StudiesEarly Detection of CancerFemaleGastrectomyGastritisGPI-Linked ProteinsHelicobacter pyloriHumansMaleNeoplasm Recurrence, LocalAntibodies, BacterialAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-19-9 AntigenCA-72-4 antigenCarcinoembryonic AntigenCEACAM5 protein, humanGPI-Linked Proteinscarbohydrate antigendiagnosisgastric cancerhelicobacter pyloriprognosis

Identifiers

PMID32118318
PMCPMC7370745
OpenAlexW3010025268

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.