ArticleThe Journal of clinical endocrinology and metabolism2020
Recharacterizing the Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Short-Term Metabolic Adaptation: Prediction of Weight Change and Effects of Macronutrient Manipulations
Predicting Adaptive Thermogenesis
Energy Intake Response to Short-Term Alterations of Energy Expenditure in Humans
Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.The American journal of clinical nutrition · 2021Trial
- Six- and Twelve-Month Changes in Body Composition and 24-h Energy Expenditure After a Very Low-Calorie Ketogenic Diet.Obesity (Silver Spring, Md.) · 2026Observational
- Specific metabolic rate and body weight regulation: racial and ethnic differences in mass-independent energy expenditure.Journal of endocrinological investigation · 2026Article
- Hunger on the Three-Factor Eating Questionnaire Is Associated With Increased Ad Libitum Energy Intake in Different Conditions.Obesity (Silver Spring, Md.) · 2026Article
- Effects of 6-month treatment with the GLP-1 receptor agonist liraglutide on 24-hour energy metabolism and body composition in adults with obesity.Journal of endocrinological investigation · 2025Article
- Body weight regulation models in humans: insights for testing their validity.Nature reviews. Endocrinology · 2025Review
- In Search of Environmental Factors Associated With Global Differences in Birth Weight and BMI.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- The effect of a leptin phenotype on weight change and energy expenditure responses to acute and prolonged energetic stressors.American journal of physiology. Endocrinology and metabolism · 2025Article
- Distinct Roles of Common Genetic Variants and Their Contributions to Diabetes: MODY and Uncontrolled T2DM.Biomolecules · 2025Review
- Parsing reward sensitivity reveals distinct relationships with energy intake, metabolic markers, physical activity and fitness.Acta neuropsychiatrica · 2025Article
- Greater anhedonia scores in healthy individuals are associated with less decline in 24-hour energy expenditure with fasting: Evidence for a link between behavioral traits and spendthrift phenotype.Physiology & behavior · 2023Article
- Effects of Short-term Fasting on Ghrelin/GH/IGF-1 Axis in Healthy Humans: The Role of Ghrelin in the Thrifty Phenotype.The Journal of clinical endocrinology and metabolism · 2022Article
- Metabolic profile in women differs between high versus low energy spenders during a low intensity exercise on a cycle-desk.Scientific reports · 2022Article
- The counterbalancing effects of energy expenditure on body weight regulation: Orexigenic versus energy-consuming mechanisms.Obesity (Silver Spring, Md.) · 2022Article
- Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype.Metabolism: clinical and experimental · 2021Article
- Pathophysiology of Neurogenic Obesity After Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2021Review
- Article
- Recharacterizing the Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.The Journal of clinical endocrinology and metabolism · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe human thrifty phenotype hypothesis presupposes that lower 24-hour (24h) energy expenditure (24EE) during famine preserves body mass and promotes survival. The prevailing view defines thrifty individuals as having a lower 24EE during fasting. However, it is also plausible that the greater decline in 24EE during fasting in thrifty individuals is due to higher 24EE during energy balance conditions (ENBAL). Herein, we provide evidence that this is indeed the case.
methodsIn 108 healthy subjects, 24EE was measured in a whole-room indirect calorimeter both during ENBAL and 24h fasting conditions. Subjects were categorized as thrifty or spendthrift based on the median value (-162 kcal/day) of the difference in 24EE (adjusted for body composition) between fasting and ENBAL conditions. Concomitant 24h urinary catecholamines were assessed by liquid chromatography-mass spectrometry.
resultsCompared to ENBAL, 24EE decreased during 24h fasting by 172 kcal/day (standard deviation = 93; range, -470 to 122). A greater-than-median decrease in 24EE ("thriftier" phenotype) was due to higher 24EE during ENBAL (+124 kcal/day; P < 0.0001) but not to lower 24EE during fasting (P = 0.35). Greater fasting-induced increase in epinephrine was associated with concomitant lower decrease in 24EE (r = 0.27; P = 0.006). MAIN
conclusionThe greater decrease in 24EE during acute fasting (which characterizes the thrifty phenotype) is not due to reduced metabolic rate during fasting but to a relatively higher 24EE during feeding conditions, and this decrease in 24EE during fasting is accompanied by a smaller increase in epinephrine. These results recharacterize the prevailing view of the short-term 24EE responses that define the human metabolic phenotypes. Clinical Trials: NCT00523627, NCT00687115, NCT02939404.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.