Evidence map›Paper›PMID 32118201›Full record

ReviewJHEP reports : innovation in hepatology2020

Limitations of non-invasive tests for assessment of liver fibrosis.

Keyur Patel, Giada Sebastiani

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JHEP reports : innovation in hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05301231 (Omics-based Predictors of NAFLD/Potential NASH), which is not on this map. Cited by 176 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 6 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05301231 unknown statusnot on this mapstarted 2022, after this paper: background citation

Omics-based Predictors of NAFLD/Potential NASH: A New Era Towards Valid and Reliable Non-invasive Diagnosis and Personalized Therapy

Typeobservational_patient_registrySponsorNational Research Centre, EgyptRan2022 to 2024Enrolled450ConditionsNon-Alcoholic Fatty Liver Disease, Non Alcoholic SteatohepatitisArmsGenomics (DNA Extraction), Epi-genomics, Proteomics (Glycoproteomics), Salivary Metabolomics, Individualized counselling for behavioural modification
3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 6 syntheses or guidelines pooled it, 291 citations in OpenAlex.

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  9. Efficacy of combining pentoxiphylline and vitamin E versus vitamin E alone in non-alcoholic steatohepatitis- A randomized pilot study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Keyur PatelDivision of Gastroenterology, University Health Network Toronto, Toronto General Hospital, Toronto, ON, Canada.
Giada SebastianiDivision of Gastroenterology and Hepatology, McGill University Health Center, Montreal, QC, Canada.
McGill University Health Centre · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnostic assessment of liver injury is an important step in the management of patients with chronic liver disease (CLD). Although liver biopsy is the reference standard for the assessment of necroinflammation and fibrosis, the inherent limitations of an invasive procedure, and need for repeat sampling, have led to the development of several non-invasive tests (NITs) as alternatives to liver biopsy. Such non-invasive approaches mostly include biological (serum biomarker algorithms) or physical (imaging assessment of tissue stiffness) assessments. However, currently available NITs have several limitations, such as variability, inadequate accuracy and risk factors for error, while the development of a newer generation of biomarkers for fibrosis may be limited by the sampling error inherent to the reference standard. Many of the current NITs were initially developed to diagnose significant fibrosis in chronic hepatitis C, subsequently refined for the diagnosis of advanced fibrosis in patients with non-alcoholic fatty liver disease, and further adapted for prognostication in CLD. An important consideration is that despite their increased use in clinical practice, these NITs were not designed to reflect the dynamic process of fibrogenesis, differentiate between adjacent disease stages, diagnose non-alcoholic steatohepatitis, or follow longitudinal changes in fibrosis or disease activity caused by natural history or therapeutic intervention. Understanding the strengths and limitations of these NITs will allow for more judicious interpretation in the clinical context, where NITs should be viewed as complementary to, rather than as a replacement for, liver biopsy.

Indexed as

AGA, American Gastroenterology AssociationALT, alanine aminotransferaseAPRI, AST-platelet ratio indexAST, aspartate aminotransferaseAUC, area under the curveBiomarkersBMI, body mass indexCAP, controlled attenuation parameterCHB, chronic hepatitis BCHC, chronic hepatitis CCLD, chronic liver diseaseCPA, collagen proportionate areaDAA, direct-acting antiviralElastographyELF, enhanced liver fibrosisFIB-4, fibrosis-4FLIP, fatty liver inhibition of progressionHCC, hepatocellular carcinomaIFN, interferonLiver biopsyLSM, liver stiffness measureMRE, magnetic resonance elastographyMR, magnetic resonanceNAFLD, non-alcoholic fatty liver diseaseNFS, NAFLD fibrosis scoreNITs, non-invasive testsNon-alcoholic fatty liver diseaseSVR, sustained virologic responseUS, ultrasoundVCTE, vibration-controlled transient elastographyViral hepatitis

Identifiers

PMID32118201
PMCPMC7047178
OpenAlexW3002581322

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.