ArticleFrontiers in veterinary science2020
Heat Stress Causes Immune Abnormalities via Massive Damage to Effect Proliferation and Differentiation of Lymphocytes in Broiler Chickens.
Article in Frontiers in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Meta-Analysis of the Efficacy of Spirulina Intervention in Mitigating the Negative Impact of Heat Stress on Production Physiology and Health Indices of Broilers.Journal of animal physiology and animal nutrition · 2026Pooled it
- Meta-Analysis and Systematic Review of the Thermal Stress Response:Frontiers in physiology · 2022Pooled it
- A Review on Heat Stress in Broiler Chickens: Mechanisms, Effects and Mitigation Strategies.Veterinary medicine and science · 2026Review
- Article
- Naringenin alleviates heat stress-induced thymic injury through a triple mechanism of immune modulation, antioxidant defense, and inflammation suppression.Poultry science · 2026Article
- Prevalence and Age-Associated Bacterial Chondronecrosis with Osteomyelitis Lesions in Commercial Broiler Flocks in Central Java, Indonesia.Animals : an open access journal from MDPI · 2026Article
- Total saponins of Gynostemma pentaphyllum mitigate chronic heat stress-induced thymus and spleen inflammation in broilers via NF-κB pathway activation.Poultry science · 2026Article
- Essential Oil Blend and Ascorbic Acid Supplementation Improves Performance, Semen Characteristics, Redox Balance, and Intestinal Integrity in Heat-Stressed Male Rabbits.Veterinary sciences · 2026Article
- Thermal stress responses and heat stress resilience genes in chickens are revealed through genomic and transcriptomic insights.Journal of animal science and biotechnology · 2026Review
- Avian Candidiasis: A Comprehensive Review of Pathogenesis, Diagnosis, and Control.Veterinary sciences · 2026Review
- Dietary vitamin E and selenium supplementation improve hematological responses and productivity of growing goats consuming diluted seawater under tropical conditions.Veterinary world · 2026Article
- Alginate oligosaccharides derived from tropical brown seaweeds as sustainable alternatives to antibiotic growth promoters in poultry nutrition: Functional mechanisms and production perspectives.Veterinary world · 2026Review
- Multidimensional regulatory mechanisms of chicken immunity: focus on viral infection, intestinal microbiota and heat stress.Frontiers in veterinary science · 2026Review
- Role ofVeterinary sciences · 2025Article
- Transport Vehicles as a Vector of Goose Parvovirus Infections (GPV).Animals : an open access journal from MDPI · 2025Article
- Effects of Bacillus subtilis and Lactobacillus on production performance, meat quality, serum immunoglobulins, immune organ indices and redox status in heat-stressed broilers.Tropical animal health and production · 2025Article
- Salicylic acid supplementation for broiler chickens under heat stress.Open veterinary journal · 2025Review
- Integrated metabolome and immunity analysis of immune-physiological responses in dairy cows under heat stress condition.Animal bioscience · 2025Article
- Simvastatin Combined with CpG Enhances the Immunogenicity of the H9N2 Inactivated Vaccine.Veterinary sciences · 2025Article
- Nutritional strategies to alleviate heat stress in broiler chickens and laying hens: role of functional nutrients.Journal of animal science and technology · 2025Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Broiler chickens are highly sensitive to high ambient temperatures due to their feathers, lack of skin sweat glands, and high productivity. Heat stress (HS) is a major concern for the poultry industry because it negatively affects growth as well as immune functions, which increase the potential risk of infectious disease outbreaks. Therefore, it is vital to elucidate HS's effect on the avian immune system, especially considering the global rise in average surface temperature. Our study identified a series of immunological disorders in heat-stressed broiler chickens. We exposed 22-day-old broiler chickens to a continuous HS condition (34.5 ± 0.5°C) for 14 days and immunized them with a prototype bovine serum albumin (BSA) antigen. The plasma and lymphoid tissues (thymus, bursa of Fabricius, and spleen) were harvested at the end of the experiments to investigate the induction of BSA-specific immune responses. Our results revealed that plasma titers of immunoglobulin (Ig)Y, IgM, and IgA antibodies specific for BSA were lower than those of thermoneutral chickens immunized with BSA. Furthermore, the spleens of the heat-stressed broiler chickens displayed severe depression of Bu1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.