ReviewFrontiers in cell and developmental biology2020
Cytoskeleton Force Exertion in Bulk Cytoplasm.
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A continuous-discrete model of cell contraction incorporating actin and intermediate filaments.iScience · 2026Article
- Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.Cellular and molecular life sciences : CMLS · 2025Review
- Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes.Nature communications · 2025Article
- Multimodal Characterization of Cortical Neuron Response to Permanent Magnetic Field Induced Nanomagnetic Force Maps.ACS nano · 2024Article
- Deciphering the intracellular forces shaping mitochondrial motion.Scientific reports · 2024Article
- Crowding alters F-actin secondary structure and hydration.Communications biology · 2023Article
- Yolk granule fusion and microtubule aster formation regulate cortical granule translocation and exocytosis in zebrafish oocytes.PLoS biology · 2023Article
- Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Manipulation of New Fluorescent Magnetic Nanoparticles with an Electromagnetic Needle, Allowed Determining the Viscosity of the Cytoplasm of M-HeLa Cells.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Optogenetic EB1 inactivation shortens metaphase spindles by disrupting cortical force-producing interactions with astral microtubules.Current biology : CB · 2022Article
- Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues.Biophysics reviews · 2022Review
- Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- DNA Conformation Dictates Strength and Flocculation in DNA-Microtubule Composites.ACS macro letters · 2021Article
- Mechanical Mechanisms of Chromosome Segregation.Cells · 2021Review
- Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microtubule and actin cytoskeletons generate forces essential to position centrosomes, nuclei, and spindles for division plane specification. While the largest body of work has documented force exertion at, or close to the cell surface, mounting evidence suggests that cytoskeletal polymers can also produce significant forces directly from within the cytoplasm. Molecular motors such as kinesin or dynein may for instance displace cargos and endomembranes in the viscous cytoplasm yielding friction forces that pull or push microtubules. Similarly, the dynamics of bulk actin assembly/disassembly or myosin-dependent contractions produce cytoplasmic forces which influence the spatial organization of cells in a variety of processes. We here review the molecular and physical mechanisms supporting bulk cytoplasmic force generation by the cytoskeleton, their limits and relevance to organelle positioning, with a particular focus on cell division.
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