Evidence map›Paper›PMID 32117972›Full record

ReviewFrontiers in cell and developmental biology2020

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer.

Joseph Sia, Radoslaw Szmyd, Eric Hau, Harriet E Gee

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07554677 (Feasibility of a Co-designed PRe-radiotherapy Exercise Programme for People With Stage I-III Non-small Cell Lung cAnCEr), which is not on this map. Cited by 212 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 1 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07554677 narecruitingnot on this mapstarted 2026, after this paper: background citation

Feasibility of a Co-designed PRe-radiotherapy Exercise Programme for People With Stage I-III Non-small Cell Lung cAnCEr: A Single-centre, Single Arm Pilot Study

TypeinterventionalSponsorQueen's University, BelfastRan2026 to 2026Enrolled30ConditionsLung CancerArmsExercise, radiotherapy
3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 1 synthesis or guideline pooled it, 356 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. [Research square · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Engineering Oncolytic Virus-Armed Macrophages for Enhanced Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Tumor organoids modeling reveals timed responses and interplay of radiotherapy and chemotherapy in pancreatic cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
    Article
  13. Integrated approaches to sensitizing melanoma to radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Joseph SiaDepartment of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Radoslaw SzmydChildren's Medical Research Institute, Sydney, NSW, Australia.
Eric HauSydney West Radiation Oncology Network, Sydney, NSW, Australia.
Harriet E GeeSydney West Radiation Oncology Network, Sydney, NSW, Australia.
Sydney Children’s Hospitals Network · AUChildren's Medical Research Institute · AUPeter MacCallum Cancer Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation therapy (RT) is responsible for at least 40% of cancer cures, however treatment resistance remains a clinical problem. There have been recent advances in understanding the molecular mechanisms of radiation-induced cell death. The type of cell death after radiation depends on a number of factors including cell type, radiation dose and quality, oxygen tension,

Indexed as

abscopal effectcell deathimmunogenic cell deathradiation therapyradiotherapystereotactic ablative radiotherapy

Identifiers

PMID32117972
PMCPMC7031160
OpenAlexW3005837382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.