Evidence map›Paper›PMID 32117962›Full record

ArticleFrontiers in cell and developmental biology2020

Irradiation Induces Epithelial Cell Unjamming.

Michael J O'Sullivan, Jennifer A Mitchel, Amit Das, Stephan Koehler, Herbert Levine, Dapeng Bi, Zachary D Nagel, Jin-Ah Park

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity.American journal of respiratory cell and molecular biology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. In well-differentiated primary human bronchial epithelial cells, TGF-American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael J O'SullivanDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Jennifer A MitchelDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Amit DasDepartment of Physics, Northeastern University, Boston, MA, United States.
Stephan KoehlerDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Herbert LevineDepartment of Physics, Northeastern University, Boston, MA, United States.
Dapeng BiDepartment of Physics, Northeastern University, Boston, MA, United States.
Zachary D NagelDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Jin-Ah ParkDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Harvard University · USNortheastern University · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
Epithelial layer jamming in breast cancer cell migrationU01CA202123 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2015 to 2019
$3.4M
Physics of bronchial epithelial unjammingR01HL148152 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, PARK, JIN-AH · 2019 to 2022
$2.2M
NCI NIH HHS U01 CA202123NHLBI NIH HHS P01 HL120839NHLBI NIH HHS R01 HL148152NHLBI NIH HHS T32 HL007118NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

The healthy and mature epithelial layer is ordinarily quiescent, non-migratory, solid-like, and jammed. However, in a variety of circumstances the layer transitions to a phase that is dynamic, migratory, fluid-like and unjammed. This has been demonstrated in the developing embryo, the developing avian airway, the epithelial layer reconstituted

Indexed as

cancerepitheliumirradiationmetastasismigrationunjamming

Identifiers

PMID32117962
PMCPMC7026004
OpenAlexW2999919476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.