Evidence map›Paper›PMID 32117908›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Prioritizing Gene Cascading Paths to Model Colorectal Cancer Through Engineered Organoids.

Yanyan Ping, Chaohan Xu, Liwen Xu, Gaoming Liao, Yao Zhou, Chunyu Deng, Yujia Lan, Fulong Yu, Jian Shi, Li Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Functional role of small extrachromosomal circular DNA in colorectal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yanyan PingCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Chaohan XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Liwen XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Gaoming LiaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Yao ZhouCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Chunyu DengCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Yujia LanCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Fulong YuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Jian ShiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Li WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Yun XiaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Xia LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineered organoids by sequential introduction of key mutations could help modeling the dynamic cancer progression. However, it remains difficult to determine gene paths which were sufficient to capture cancer behaviors and to broadly explain cancer mechanisms. Here, as a case study of colorectal cancer (CRC), functional and dynamic characterizations of five types of engineered organoids with different mutation combinations of five driver genes (

Indexed as

colorectal cancerengineered organoidsgene cascading pathsprioritizingrandom walk with restart

Identifiers

PMID32117908
PMCPMC7010597
OpenAlexW3004698597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.