Evidence map›Paper›PMID 32117864›Full record

ArticleFrontiers in chemistry2020

Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-Based Sialylation in Human Breast Cells: Implications for Cancer Progression.

Christopher T Saeui, Kyung-Cho Cho, Vrinda Dharmarha, Alison V Nairn, Melina Galizzi, Sagar R Shah, Prateek Gowda, Marian Park, Melissa Austin, Amelia Clarke and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Christopher T SaeuiDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Kyung-Cho ChoDepartment of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD, United States.
Vrinda DharmarhaDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Alison V NairnComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Melina GalizziComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Sagar R ShahDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Prateek GowdaDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Marian ParkDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Melissa AustinDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Amelia ClarkeDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Edward CaiDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Matthew J BuettnerDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Ryan ArissDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Kelley W MoremenComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Hui ZhangDepartment of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD, United States.
Kevin J YaremaDepartment of Biomedical Engineering, Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, United States.
Johns Hopkins University · USUniversity of Georgia · US

Funding

TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI LIVE, DAVID H · 2012 to 2019
$14.5M
Probing the Connections between Monosaccharide Analogs, Sialic Acid Metabolism, aR01CA112314 · NCI · JOHNS HOPKINS UNIVERSITY · PI YAREMA, KEVIN J · 2005 to 2022
$4.5M
Inhibiting UAP1/2 as a Novel Strategy for Regulating Carbohydrate Metabolic FluxF31CA192767 · NCI · JOHNS HOPKINS UNIVERSITY · PI SAEUI, CHRISTOPHER · 2015 to 2016
$87k
NCI NIH HHS F31 CA192767NCI NIH HHS R01 CA112314NIGMS NIH HHS P41 GM103390
6 · The paper itself

Abstract

Sialylation, a post-translational modification that impacts the structure, activity, and longevity of glycoproteins has been thought to be controlled primarily by the expression of sialyltransferases (STs). In this report we explore the complementary impact of metabolic flux on sialylation using a glycoengineering approach. Specifically, we treated three human breast cell lines (MCF10A, T-47D, and MDA-MB-231) with 1,3,4-O-Bu

Indexed as

breast cancerManNAc analogsmetabolic fluxmetabolic glycoengineeringsialic acidsialylation

Identifiers

PMID32117864
PMCPMC7013041
OpenAlexW3004558129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.