ReviewFrontiers in pediatrics2020
Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.
Review in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 106 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of usıng Breast mılk pacıfıer, Sucrose pacıfıer and pacıfıer ın reducıng the paın That Occurs durıng orogastrıc Tube ınsertıon ın Preterm Newborns
Effects of Neonatal Therapeutic Touch and Massage in Very Preterm and Extremely Preterm Neonates: A Randomized Controlled Trial
Who cites it
106 citing papers in PubMed, 10 syntheses or guidelines pooled it, 238 citations in OpenAlex.
- The comparative efficacy and safety of sweet solutions to reduce preterm infants' pain levels: a systematic review and network meta-analysis.Systematic reviews · 2026Pooled it
- Long-term alterations in pain sensitivity following preterm birth: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Sucrose or glucose compared to breast milk for pain control in preterm infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Frenectomy for ankyloglossia in children under five: a systematic review and meta-analysis on breastfeeding outcomes.International breastfeeding journal · 2025Pooled it
- Clinical rating scales for assessing pain in newborn infants.The Cochrane database of systematic reviews · 2025Pooled it
- Positioning for lumbar puncture in newborn infants.The Cochrane database of systematic reviews · 2023Pooled it
- Positioning for lumbar puncture in newborn infants.The Cochrane database of systematic reviews · 2023Pooled it
- Adverse childhood experience is associated with an increased risk of reporting chronic pain in adulthood: a stystematic review and meta-analysis.European journal of psychotraumatology · 2023Pooled it
- Interventions for the Management of Pain and Sedation in Newborns Undergoing Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy: A Systematic Review.Paediatric drugs · 2023Pooled it
- Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia.The Cochrane database of systematic reviews · 2022Pooled it
- The efficacy of oral sucrose for relieving lumbar puncture pain in neonates: a randomised clinical trial.BMJ paediatrics open · 2026Trial
- Oral Melatonin for Pain Relief During Venepuncture in Neonates- a Pilot Randomized Control Trial.European journal of clinical pharmacology · 2025Trial
- Effect of a portable therapeutic baby nest designed for neonates on physiological parameters, comfort and pain levels during venous blood sampling: a randomised controlled trial.Emergency medicine journal : EMJ · 2025Trial
- The Effect of Auricular Massage on Naso-Oral Suctioning Procedural Pain in Premature Neonates: A Randomized Controlled Crossover Study.TheScientificWorldJournal · 2025Trial
- Impact of breast milk on cortical pain response in newborns during the heel prick procedure: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Comparison of Sucrose vs. Swaddling in Pain Management during Birth Dose of Hepatitis B Vaccine: A Randomized Control Trial.Indian journal of pediatrics · 2024Trial
- Efficacy of Breast Milk Olfactory and Gustatory Interventions on Neonates' Biobehavioral Responses to Pain during Heel Prick Procedures.International journal of environmental research and public health · 2022Trial
- Preterm infants with severe brain injury demonstrate unstable physiological responses during maternal singing with music therapy: a randomized controlled study.European journal of pediatrics · 2021Trial
- Vascular access management plan (VAMP): neonatal European vascular access team-ESPR Recommendation 1.Pediatric research · 2026Article
- Local anesthetic techniques for analgesia in neonatal circumcision: a network meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Modern health care has brought our society innumerable benefits but has also introduced the experience of pain very early in life. For example, it is now routine care for newborns to receive various injections or have blood drawn within 24 h of life. For infants who are sick or premature, the pain experiences inherent in the required medical care are frequent and often severe, with neonates requiring intensive care admission encountering approximately fourteen painful procedures daily in the hospital. Given that much of the world has seen a steady increase in preterm births for the last several decades, an ever-growing number of babies experience multiple painful events before even leaving the hospital. These noxious events occur during a critical period of neurodevelopment when the nervous system is very vulnerable due to immaturity and neuroplasticity. Here, we provide a narrative review of the literature pertaining to the idea that early life pain has significant long-term effects on neurosensory, cognition, behavior, pain processing, and health outcomes that persist into childhood and even adulthood. We refer to clinical and pre-clinical studies investigating how early life pain impacts acute pain later in life, focusing on animal model correlates that have been used to better understand this relationship. Current knowledge around the proposed underlying mechanisms responsible for the long-lasting consequences of neonatal pain, its neurobiological and behavioral effects, and its influence on later pain states are discussed. We conclude by highlighting that another important consequence of early life pain may be the impact it has on later chronic pain states-an area of research that has received little attention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.