Evidence map›Paper›PMID 32117815›Full record

ArticleFrontiers in cellular and infection microbiology2020

Memantine Displays Antimicrobial Activity by Enhancing

Liang Peng, Li Li, Xiao-Long He, Jing-Yi Yu, Zhi-Jie Zeng, Wei-Jun Yang, Bao Zhang, Tie-Song Zhang, Hong Cao, Sheng-He Huang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Liang PengDepartment of Clinical Laboratory, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li LiKunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming, China.
Xiao-Long HeGuangdong Provincial Key Laboratory of Tropical Diseases, Department of Microbiology, Southern Medical University, Guangzhou, China.
Jing-Yi YuDepartment of Pediatrics, Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States.
Zhi-Jie ZengGuangdong Provincial Key Laboratory of Tropical Diseases, Department of Microbiology, Southern Medical University, Guangzhou, China.
Wei-Jun YangGuangdong Provincial Key Laboratory of Tropical Diseases, Department of Microbiology, Southern Medical University, Guangzhou, China.
Bao ZhangDepartment of Pediatrics, Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States.
Tie-Song ZhangKunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming, China.
Hong CaoGuangdong Provincial Key Laboratory of Tropical Diseases, Department of Microbiology, Southern Medical University, Guangzhou, China.
Sheng-He HuangKunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming, China.
Li-Qun LiuDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Southern Medical University · CNKunming Children's Hospital · CNCentral South University · CNGuangzhou Medical University · CNUniversity of Southern California · US

Funding

Role of Vimentin in Pathogenesis of CNS InflammationR21NS083967 · NINDS · CHILDREN'S HOSPITAL OF LOS ANGELES · PI HUANG, SHENG-HE · 2013 to 2014
$443k
NINDS NIH HHS R21 NS083967
6 · The paper itself

Abstract

Bacterial infection remains one of the leading causes of death worldwide due to the continuous rise of multiple antibiotic-resistant bacteria. Focusing solely on bacteria as the drug targets is a major limitation inherent in the conventional antibiotic therapy. Recently, host-directed therapies have become such an innovative approach to modulate the host defense system and the interplay of innate and adaptive immunity. Our previous studies showed that memantine (MEM), an α7 nAChR antagonist, could efficiently block multi-drug resistant

Indexed as

Extracellular TrapsMeningitisAnimalsEscherichia coliMemantineMiceNeutrophilsMemantineantibiotic resistancebacterial infectionmemantineneutrophil extracellular trapsα7 nAChR

Identifiers

PMID32117815
PMCPMC7031421
OpenAlexW3006356943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.