ReviewCureus2020
The Quest for Optimal Fractionation Schedules in Stereotactic Radiotherapy.
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Article
- Characterization of the Response of 9L and U-251N Orthotopic Brain Tumors to 3D Conformal Radiation Therapy.Radiation research · 2023Article
- Retrospective study of hypofractionated stereotactic radiotherapy combined with whole brain radiotherapy for patients with brain metastases.Radiation oncology (London, England) · 2022Article
- First Evaluation of Temporal and Spatial Fractionation in Proton Minibeam Radiation Therapy of Glioma-Bearing Rats.Cancers · 2021Article
- Dual-Tracer Assessment of Dynamic Changes in Reoxygenation and Proliferation Decrease During Fractionated Radiotherapy in Murine Tumors.Frontiers in oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In stereotactic radiotherapy (SRT), treatment with a single high dose is usually feasible as it spares the surrounding normal tissues, especially for intracranial lesions. However, single-fraction treatment may not be ideal in terms of efficacy. Single-dose treatment is particularly inefficient for tumors with hypoxia. Generally, tumors with a size of over 1 cm in diameter are considered to contain hypoxic cells, but the radioresistance of hypoxic cells can be partly overcome by fractionation owing to the reoxygenation of hypoxic tumor cells between fractions. In this article, we discuss the radiobiological characteristics of fractionated stereotactic irradiation (STI). And, based on our observations, we recommend that a dose of 54-60 Gy in six-eight fractions delivered two or three times a week for lung and other tumors larger than 2 cm in diameter is the ideal method of SRT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.