Evidence map›Paper›PMID 32117329›Full record

ArticleFrontiers in plant science2019

Epigenetic Footprints of CRISPR/Cas9-Mediated Genome Editing in Plants.

Jun Hyung Lee, Mitra Mazarei, Alexander C Pfotenhauer, Aubrey B Dorrough, Magen R Poindexter, Tarek Hewezi, Scott C Lenaghan, David E Graham, C Neal Stewart

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Advances in Plant Epigenome Editing Research and Its Application in Plants.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Various Aspects of a Gene Editing System-CRISPR-Cas9.International journal of molecular sciences · 2020
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jun Hyung LeeDepartment of Plant Sciences, University of Tennessee, Knoxville, TN, United States.
Mitra MazareiDepartment of Plant Sciences, University of Tennessee, Knoxville, TN, United States.
Alexander C PfotenhauerCenter for Agricultural Synthetic Biology, University of Tennessee Institute of Agriculture, Knoxville, TN, United States.
Aubrey B DorroughDepartment of Plant Sciences, University of Tennessee, Knoxville, TN, United States.
Magen R PoindexterDepartment of Plant Sciences, University of Tennessee, Knoxville, TN, United States.
Tarek HeweziDepartment of Plant Sciences, University of Tennessee, Knoxville, TN, United States.
Scott C LenaghanCenter for Agricultural Synthetic Biology, University of Tennessee Institute of Agriculture, Knoxville, TN, United States.
David E GrahamBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.
C Neal StewartDepartment of Plant Sciences, University of Tennessee, Knoxville, TN, United States.
University of Tennessee at Knoxville · USOak Ridge National Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR/Cas9 has been widely applied to various plant species accelerating the pace of plant genome editing and precision breeding in crops. Unintended effects beyond off-target nucleotide mutations are still somewhat unexplored. We investigated the degree and patterns of epigenetic changes after gene editing. We examined changes in DNA methylation in genome-edited promoters of naturally hypermethylated genes (AT1G72350 and AT1G09970) and hypomethylated genes (AT3G17320 and AT5G28770) from

Indexed as

bisulfite sequencingCRISPR/Cas9DNA methylationepigenetic changegenome editing

Identifiers

PMID32117329
PMCPMC7026911
OpenAlexW3004083769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.