Evidence map›Paper›PMID 32117318›Full record

ArticleFrontiers in immunology2020

Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury.

Nobuyuki Nosaka, Daisy Martinon, Debbie Moreira, Timothy R Crother, Moshe Arditi, Kenichi Shimada

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
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  8. Octreotide and direct/indirect lung injury.Research in pharmaceutical sciences · 2025
    Review
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  13. Review
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  16. Article
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  20. Enhancing autophagy in CD11cCell reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nobuyuki NosakaDivision of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Daisy MartinonDivision of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Debbie MoreiraDivision of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Timothy R CrotherDivision of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Moshe ArditiDivision of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Kenichi ShimadaDivision of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Cedars-Sinai Medical Center · US

Funding

Sequential release of IL-1alpha and IL-1beta leads to a two-hit model of acute lung injuryR01HL130353 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHIMADA, KENICHI · 2016 to 2020
$2.2M
NHLBI NIH HHS R01 HL130353
6 · The paper itself

Abstract

Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and ventilator-induced lung injury (VILI). Autophagy is a key regulator of inflammasome activation in macrophages. Here, we investigated the role of autophagy in the development of acute lung injury (ALI) induced by lipopolysaccharide (LPS) and mechanical ventilation (MV). Two hours before starting MV, 0.2 mg/kg LPS was administered to mice intratracheally. Mice were then placed on high-volume MV (30 ml/kg with 3 cmH

Indexed as

AnimalsAutophagyDown-RegulationHypoxiaInflammasomesInterleukin-18Interleukin-1betaLipopolysaccharidesLungMaleMiceMice, Inbred C57BLPermeabilityTOR Serine-Threonine KinasesTrehaloseVentilator-Induced Lung InjuryInflammasomesInterleukin-18Interleukin-1betaLipopolysaccharidesmTOR protein, mouseTOR Serine-Threonine KinasesTrehaloseacute lung injuryautophagyIL-1βinflammasomelipopolysaccharidemacrophagemechanical ventilation

Identifiers

PMID32117318
PMCPMC7033480
OpenAlexW3006673111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.