Evidence map›Paper›PMID 32117312›Full record

ArticleFrontiers in immunology2020

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4

Kari Guderud, Line H Sunde, Siri T Flåm, Marthe T Mæhlen, Maria D Mjaavatten, Siri Lillegraven, Anna-Birgitte Aga, Ida M Evenrød, Ellen S Norli, Bettina K Andreassen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. International journal of molecular medicine · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. An update on epigenetic regulation in autoimmune diseases.Journal of translational autoimmunity · 2022
    Article
  17. Review
  18. Genetics of rheumatoid arthritis.Seminars in immunopathology · 2022
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Kari GuderudDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
Line H SundeDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
Siri T FlåmDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
Marthe T MæhlenDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Maria D MjaavattenDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Siri LillegravenDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Anna-Birgitte AgaDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Ida M EvenrødDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
Ellen S NorliDepartment of Rheumatology, Martina Hansens Hospital, Bærum, Norway.
Bettina K AndreassenDepartment of Research, Cancer Registry of Norway, Institute for Population-Based Research, Oslo, Norway.
Sören FranzenburgInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Espen A HaavardsholmDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Simon RaynerDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
Kristina GervinPharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, School of Pharmacy, University of Oslo, Oslo, Norway.
Benedicte A LieDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
Diakonhjemmet Hospital · NOUniversity of Oslo · NOOslo University Hospital · NOChristian-Albrechts-Universität zu Kiel · DECancer Registry of Norway · NOMartina Hansens Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationImmunologic MemoryAdultAgedArthritis, RheumatoidCD4-Positive T-LymphocytesCpG IslandsFemaleGene OntologyHumansMaleMethotrexateMiddle AgedPolymorphism, Single NucleotideMethotrexateCD4 memoryCD4 naïveDNA methylationepigeneticmethotrexaterheumatoid arthritisRRBST cells

Identifiers

PMID32117312
PMCPMC7033478
OpenAlexW3006394248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.