Evidence map›Paper›PMID 32117265›Full record

ReviewFrontiers in immunology2020

Feed, Microbiota, and Gut Immunity: Using the Zebrafish Model to Understand Fish Health.

Adrià López Nadal, Wakako Ikeda-Ohtsubo, Detmer Sipkema, David Peggs, Charles McGurk, Maria Forlenza, Geert F Wiegertjes, Sylvia Brugman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 251 citations in OpenAlex.

  1. Pooled it
  2. Gut microbes · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Developmental regulation of intestinalbioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Peptide GTSFTTTAER FromFood science & nutrition · 2025
    Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Adrià López NadalCell Biology and Immunology Group, Wageningen University and Research, Wageningen, Netherlands.
Wakako Ikeda-OhtsuboLaboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Detmer SipkemaMicrobiology, Wageningen University and Research, Wageningen, Netherlands.
David PeggsSkretting Aquaculture Research Centre, Stavanger, Norway.
Charles McGurkSkretting Aquaculture Research Centre, Stavanger, Norway.
Maria ForlenzaCell Biology and Immunology Group, Wageningen University and Research, Wageningen, Netherlands.
Geert F WiegertjesAquaculture and Fisheries Group, Wageningen University and Research, Wageningen, Netherlands.
Sylvia BrugmanCell Biology and Immunology Group, Wageningen University and Research, Wageningen, Netherlands.
Wageningen University & Research · NLNorwegian Biodiversity Information Centre · NOTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquafeed companies aim to provide solutions to the various challenges related to nutrition and health in aquaculture. Solutions to promote feed efficiency and growth, as well as improving the fish health or protect the fish gut from inflammation may include dietary additives such as prebiotics and probiotics. The general assumption is that feed additives can alter the fish microbiota which, in turn, interacts with the host immune system. However, the exact mechanisms by which feed influences host-microbe-immune interactions in fish still remain largely unexplored. Zebrafish rapidly have become a well-recognized animal model to study host-microbe-immune interactions because of the diverse set of research tools available for these small cyprinids. Genome editing technologies can create specific gene-deficient zebrafish that may contribute to our understanding of immune functions. Zebrafish larvae are optically transparent, which allows for

Indexed as

Animal FeedAnimalsDietGastrointestinal MicrobiomeHumansImmunityIntestinesMicrobial InteractionsMicrobiotaModels, AnimalPrebioticsProbioticsZebrafishPrebioticsgutimmunityintestinemicrobiotaprebioticsprobioticszebrafish

Identifiers

PMID32117265
PMCPMC7014991
OpenAlexW3004807746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.