Evidence map›Paper›PMID 32117259›Full record

ReviewFrontiers in immunology2020

Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-Infections.

Elizabeth R Aguilera, Laurel L Lenz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Journal of thoracic disease · 2026
    Article
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  10. Review
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  12. Treatment with lipoxin AInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
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  16. Review
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  20. Human HLA prolongs the host inflammatory response inFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth R AguileraDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States.
Laurel L LenzDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States.
University of Colorado Denver · US

Funding

NK cell IL-10 production during bacterial infectionsR01AI131662 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2017 to 2021
$2.9M
Role of IFNs and IFNGR in susceptibility to bacteria in Down syndromeR21AI161827 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2021 to 2022
$421k
Myeloid cell IFNGR regulation in persistent viral and secondary bacterial infectionsR21AI140499 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2018 to 2019
$420k
NIAID NIH HHS R01 AI131662NIAID NIH HHS R21 AI140499NIAID NIH HHS R21 AI161827
6 · The paper itself

Abstract

Bacterial and viral pathogens are predominant causes of pulmonary infections and complications. Morbidity and mortality from these infections is increased in populations that include the elderly, infants, and individuals with genetic disorders such as Down syndrome. Immune senescence, concurrent infections, and other immune alterations occur in these susceptible populations, but the underlying mechanisms that dictate increased susceptibility to lung infections are not fully defined. Here, we review unique features of the lung as a mucosal epithelial tissue and aspects of inflammatory and immune responses in model pulmonary infections and co-infections by influenza virus and

Indexed as

AgedAnimalsCoinfectionCytokinesDisease Models, AnimalDisease SusceptibilityHost-Pathogen InteractionsHumansImmunity, InnateInfantInflammationInfluenza A virusInfluenza, HumanOrthomyxoviridae InfectionsPneumococcal InfectionsPneumonia, PneumococcalCytokinesbacterial infectiondown syndromeinnate immunitypulmonary inflammationviral infection

Identifiers

PMID32117259
PMCPMC7026256
OpenAlexW3005933298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.