Evidence map›Paper›PMID 32117243›Full record

ArticleFrontiers in immunology2020

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release.

Mina Mehanny, Marcus Koch, Claus-Michael Lehr, Gregor Fuhrmann

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 111 citations in OpenAlex.

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  10. Frontiers in cellular and infection microbiology · 2026
    Article
  11. Extracellular Vesicles fromMicroorganisms · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Journal of oral microbiology · 2025
    Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mina MehannyBiogenic Nanotherapeutics Group, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.
Marcus KochLeibniz-Institute for New Materials (INM) GmbH, Saarland University Saarbrücken, Saarbrücken, Germany.
Claus-Michael LehrDepartment of Pharmacy, Saarland University, Saarbrücken, Germany.
Gregor FuhrmannBiogenic Nanotherapeutics Group, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.
Helmholtz Institute for Pharmaceutical Research Saarland · DEAin Shams University · EGSaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles are membranous structures shed by almost every living cell. Bacterial gram-negative outer membrane vesicles (OMVs) and gram-positive membrane vesicles (MVs) play important roles in adaptation to the surrounding environment, cellular components' exchange, transfer of antigens and virulence factors, and infection propagation.

Indexed as

A549 CellsAnimalsCell LineCryoelectron MicroscopyCytokinesExtracellular VesiclesHost-Pathogen InteractionsHumansInterleukin-12MacrophagesMiceMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionPneumococcal InfectionsStreptococcus pneumoniaeTHP-1 CellsCytokinesInterleukin-12cytokinecytotoxicityextracellular membrane vesiclesStreptococcus pneumoniaeuptakevaccine

Identifiers

PMID32117243
PMCPMC7034238
OpenAlexW3006438727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.