Evidence map›Paper›PMID 32117240›Full record

ArticleFrontiers in immunology2020

Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis.

Dong-Young Kim, Seung-Hwan Lee, Yan Fu, Feifeng Jing, Won-Young Kim, Sang-Bum Hong, Jung-A Song, Han Choe, Hyun Jin Ryu, Minjung Kim and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Enhanced fibrotic potential of COL1A1Frontiers in cardiovascular medicine · 2024
    Article
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  8. Article
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Dong-Young KimDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Seung-Hwan LeeDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Yan FuDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Feifeng JingDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Won-Young KimDivision of Critical Care Medicine, Department of Internal Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Sang-Bum HongDivision of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jung-A SongDepartment of Physiology, University of Ulsan College of Medicine, Seoul, South Korea.
Han ChoeDepartment of Physiology, University of Ulsan College of Medicine, Seoul, South Korea.
Hyun Jin RyuDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Minjung KimDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Dahae LimDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Min-Seon KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Chae-Ok YunDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, South Korea.
Taewon LeeDivision of Applied Mathematical Sciences, College of Science and Technology, Korea University, Sejong, South Korea.
Hoon HyunDepartment of Biomedical Sciences, Chonnam National University Medical School, Gwangju, South Korea.
Eun Young ChoiDepartment of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Ulsan College · KRUniversity of Ulsan · KRAsan Medical Center · KRChonnam National University · KRChung-Ang University Hospital · KRHanyang University · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uncontrolled activation of transforming growth factor (TGF)-β results in a wide range of pathologic conditions. Therapeutic interventions to regulate TGF-β signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates fibrosis in mice by inhibiting α

Indexed as

AnimalsCalcium-Binding ProteinsCell Adhesion MoleculesMiceMice, Inbred C57BLPulmonary FibrosisSignal TransductionTransforming Growth Factor betaCalcium-Binding ProteinsCell Adhesion MoleculesEDIL3 protein, humanEdil3 protein, mouseTransforming Growth Factor betaDel-1 (developmental endothelial locus-1)fibrosisinflammationintegrinstransforming growth factor-beta activation

Identifiers

PMID32117240
PMCPMC7018852
OpenAlexW3004479621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.