ReviewFrontiers in microbiology2020
Mining the Human Host Metabolome Toward an Improved Understanding of Malaria Transmission.
Review in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Temporal multi-tissue profiling reveals metabolites linked to immune response and malaria parasitemia control.iScience · 2026Article
- Metabolomics meets systems immunology.EMBO reports · 2023Review
- Predicting microbe organisms using data of living micro forms of life and hybrid microbes classifier.PloS one · 2023Article
- Metabolome modulation of the host adaptive immunity in human malaria.Nature metabolism · 2021Article
- Variability in human attractiveness to mosquitoes.Current research in parasitology & vector-borne diseases · 2021Review
- Insights into malaria pathogenesis gained from host metabolomics.PLoS pathogens · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The big data movement has led to major advances in our ability to assess vast and complex datasets related to the host and parasite during malaria infection. While host and parasite genomics and transcriptomics are often the focus of many computational efforts in malaria research, metabolomics represents another big data type that has great promise for aiding our understanding of complex host-parasite interactions that lead to the transmission of malaria. Recent analyses of the complement of metabolites present in human blood, skin and breath suggest that host metabolites play a critical role in the transmission cycle of malaria. Volatile compounds released through breath and skin serve as attractants to mosquitoes, with malaria-infected hosts appearing to have unique profiles that further increase host attractiveness. Inside the host, fluctuations in the levels of certain metabolites in blood may trigger increased production of transmission-competent sexual stages (gametocytes), setting the stage for enhanced transmission of malaria from human to mosquito. Together, these recent discoveries suggest that metabolites of human blood, skin and breath play critical roles in malaria transmission. This review discusses recent advances in this area, with a focus on metabolites that have been identified to play a role in malaria transmission and methods that may lead to an improved understanding of malaria transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.