ReviewFrontiers in endocrinology2020
The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology.
Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Growth Hormone Administration to Improve Reproductive Outcomes in Women with Recurrent Implantation Failure (RIF): a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2023Pooled it
- Effect of zero-time exercise intervention on endometrial receptivity in women with thin endometrium a single-center randomized sham-controlled trial.Archives of gynecology and obstetrics · 2026Trial
- Growth Hormone: A Potential Treatment of Patients with Refractory Thin Endometrium: A Clinical Trial Study.International journal of fertility & sterility · 2022Trial
- Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.Materials today. Bio · 2025Article
- Novel perspectives on growth hormone regulation of ovarian function: mechanisms, formulations, and therapeutic applications.Frontiers in endocrinology · 2025Review
- Regenerative therapies for refractory thin endometrium inFrontiers in cell and developmental biology · 2025Review
- Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health.Biology of sex differences · 2024Article
- Metabolic hormones are integral regulators of female reproductive health and function.Bioscience reports · 2024Review
- Atosiban interacts with growth hormones as adjuvants in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2024Article
- Effect of growth hormone cotreatment in sub-fertile women ≥ 40 years: A Meta-analysis.Reproduction & fertility · 2023Article
- Growth hormone inhibits the JAK/STAT3 pathway by regulating SOCS1 in endometrial cellsEuropean journal of histochemistry : EJH · 2023Article
- The Effect of Human Growth Hormone on Endometrial Growth in Controlled Ovarian Hyperstimulation Cycles.Journal of personalized medicine · 2022Article
- Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options.International journal of molecular sciences · 2022Review
- Effects of Adjuvant Growth Hormone Therapy on Poor Ovarian Responders in Assisted Reproductive Technology.Maedica · 2022Article
- Importance of IGF-I levels in IVF: potential relevance for growth hormone (GH) supplementation.Journal of assisted reproduction and genetics · 2022Article
- Growth hormone in fertility and infertility: Mechanisms of action and clinical applications.Frontiers in endocrinology · 2022Review
- Resistant ovary syndrome: Pathogenesis and management strategies.Frontiers in medicine · 2022Review
- New insights in addressing endometrial dysfunction: the potential role of growth hormone.Annals of translational medicine · 2020Article
- The Impact of Growth Hormone Co-Treatment Duration on Outcomes in IVF/ICSI Cycles Among Poor Ovarian Responders.Journal of reproduction & infertilityArticle
- Human growth hormone use in poor ovarian response - caution and opportunities.Therapeutic advances in reproductive healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth hormone (GH) has been considered as an adjuvant treatment in human assisted reproductive technology (ART) for several years. Its action was largely attributed to an improvement of ovarian function and less emphasis was paid to its role in the uterus. However, there is increasing evidence that GH and its receptors are expressed and have actions in the endometrium and may play an important role in modifying endometrial receptivity. Thus, in this review, we firstly describe the existence of GH receptors in endometrium and then summarize the effects of GH on the endometrium in clinical situations and the underlying mechanisms of GH in the regulation of endometrial receptivity. Finally, we briefly review the potential risks of GH in ART and consider rationalized use of GH treatment in ART.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.