Evidence map›Paper›PMID 32116804›Full record

ArticleFrontiers in physiology2020

Near Infrared Spectroscopy Measurements of Mitochondrial Capacity Using Partial Recovery Curves.

Maxwell D Sumner, Samuel Beard, Elizabeth K Pryor, Indrajit Das, Kevin K McCully

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06083194 unknown statusnot on this mapstarted 2024, after this paper: background citation

Non-invasive Evaluation of Muscle Oxidative Capacity. Study of Its Relationship With Muscular Endurance and Fatigue in Patients With Multiple Sclerosis

TypeobservationalSponsorUniversity Hospital, Clermont-FerrandRan2024 to 2025Enrolled30ConditionsMultiple Sclerosis
NCT07654946 narecruitingnot on this mapstarted 2026, after this paper: background citation

Near-Infrared Spectroscopy-Derived Mitochondrial Oxidative Phosphorylation Capacity, Local Muscular Fatigue Resistance, and the Effects of Acute Taurine Supplementation

TypeinterventionalSponsorLouisiana State University and A&M CollegeRan2026 to 2027Enrolled34ConditionsLocal Muscular Endurance and Fatigue, NIRS Skeletal Muscle Mitochondrial Capacity, Acute Taurine SupplementationArmsAcute Taurine Supplementation, Acute Placebo Supplementation
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
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  10. Near-infrared spectroscopy (NIRS)Frontiers in physiology · 2024
    Article
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maxwell D SumnerNon-Invasive Exercise Muscle Physiology Lab, Department of Kinesiology, University of Georgia, Athens, GA, United States.
Samuel BeardNon-Invasive Exercise Muscle Physiology Lab, Department of Kinesiology, University of Georgia, Athens, GA, United States.
Elizabeth K PryorNon-Invasive Exercise Muscle Physiology Lab, Department of Kinesiology, University of Georgia, Athens, GA, United States.
Indrajit DasNon-Invasive Exercise Muscle Physiology Lab, Department of Kinesiology, University of Georgia, Athens, GA, United States.
Kevin K McCullyNon-Invasive Exercise Muscle Physiology Lab, Department of Kinesiology, University of Georgia, Athens, GA, United States.
University of Georgia · US

Funding

Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic MonitoringR42DK112497 · NIDDK · INFRARED RX, INC. · PI MCCULLY, KEVIN K. · 2019 to 2020
$1.3M
Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic MonitoringR41DK112497 · NIDDK · INFRARED RX, INC. · PI MCCULLY, KEVIN K. · 2017 to 2017
$183k
NIDDK NIH HHS R41 DK112497NIDDK NIH HHS R42 DK112497
6 · The paper itself

Abstract

backgroundNear-infrared spectroscopy (NIRS) has been used to measure muscle mitochondrial capacity (mVO PURPOSE: To determine the validity and repeatability of using a 6-occlusion protocol versus one with 22 occlusions to measure muscle mitochondrial capacity. The order effect of performing multiple Mito6 test was also evaluated.

methodIn two independent data sets (bicep

resultsWhen calculated from the same data set, the recovery rate constants were not significantly different between the 22 occlusion and 6 occlusion methods for the bicep (1.43 ± 0.33 min

conclusionThe Mito6 analysis is a valid and repeatable approach to measure mitochondrial capacity. The Mito6 protocol used fewer ischemic occlusion periods and multiple tests could be performed in succession in less time, increasing the practicality of the NIRS mitochondrial capacity test. There were no order effects for the rate constants of four repeated 6-occlusion tests of mitochondrial capacity, supporting the use of multiple tests to improve accuracy.

Indexed as

electrical stimulationhuman subjectsmuscle metabolismNIRSskeletal muscle

Identifiers

PMID32116804
PMCPMC7033681
OpenAlexW3006139799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.