ArticleFrontiers in physiology2020
Multiscale Modeling Framework of Ventricular-Arterial Bi-directional Interactions in the Cardiopulmonary Circulation.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Simulating impaired left ventricular-arterial coupling in aging and disease: a systematic review.Biomedical engineering online · 2024Pooled it
- Comparison of Invasive Versus Non-Invasive Pulse Contour-Based Cardiac Output Measurements at Rest and During Exercise in Pulmonary Hypertension.Journal of clinical medicine · 2025Article
- Dissecting contributions of pulmonary arterial remodeling to right ventricular afterload in pulmonary hypertension.Bioengineering & translational medicine · 2025Article
- Rapid estimation of left ventricular contractility with a physics-informed neural network inverse modeling approach.Artificial intelligence in medicine · 2024Article
- Role of tissue biomechanics in the formation and function of myocardial trabeculae in zebrafish embryos.The Journal of physiology · 2024Article
- Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.Scientific reports · 2023Article
- Computational modelling of multi-temporal ventricular-vascular interactions during the progression of pulmonary arterial hypertension.Journal of the Royal Society, Interface · 2022Article
- Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model.Computers in biology and medicine · 2022Article
- Data-driven computational models of ventricular-arterial hemodynamics in pediatric pulmonary arterial hypertension.Frontiers in physiology · 2022Article
- Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular translational research · 2021Article
- Plasticity and Enzymatic Degradation Coupled With Volumetric Growth in Pulmonary Hypertension Progression.Journal of biomechanical engineering · 2021Article
- Inverse modeling framework for characterizing patient-specific microstructural changes in the pulmonary arteries.Journal of the mechanical behavior of biomedical materials · 2021Article
- Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.Frontiers in physiology · 2021Article
- Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.Frontiers in physiology · 2021Review
- An Introductory Overview of Image-Based Computational Modeling in Personalized Cardiovascular Medicine.Frontiers in bioengineering and biotechnology · 2020Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Ventricular-arterial coupling plays a key role in the physiologic function of the cardiovascular system. We have previously described a hybrid lumped-finite element (FE) modeling framework of the systemic circulation that couples idealized FE models of the aorta and the left ventricle (LV). Here, we describe an extension of the lumped-FE modeling framework that couples patient-specific FE models of the left and right ventricles, aorta and the large pulmonary arteries in both the systemic and pulmonary circulations. Geometries of the FE models were reconstructed from magnetic resonance (MR) images acquired in a pediatric patient diagnosed with pulmonary arterial hypertension (PAH). The modeling framework was calibrated with pressure waveforms acquired in the heart and arteries by catheterization as well as ventricular volume and arterial diameter waveforms measured from MR images. The calibrated model hemodynamic results match well with the clinically-measured waveforms (volume and pressure) in the LV and right ventricle (RV) as well as with the clinically-measured waveforms (pressure and diameter) in the aorta and main pulmonary artery. The calibrated framework was then used to simulate three cases, namely, (1) an increase in collagen in the large pulmonary arteries, (2) a decrease in RV contractility, and (3) an increase in the total pulmonary arterial resistance, all characteristics of progressive PAH. The key finding from these simulations is that hemodynamics of the pulmonary vasculature and RV wall stress are more sensitive to vasoconstriction with a 10% of reduction in the lumen diameter of the distal vessels than a 67% increase in the proximal vessel's collagen mass.
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