Evidence map›Paper›PMID 32116603›Full record

ArticleFrontiers in human neuroscience2020

Extremely Low Frequency Magnetic Fields Do Not Affect LTP-Like Plasticity in Healthy Humans.

Fioravante Capone, Giovanni Pellegrino, Francesco Motolese, Mariagrazia Rossi, Gabriella Musumeci, Vincenzo Di Lazzaro

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04836325 (Effect of Transcranial Static Magnetic Field Stimulation Over the Primary Motor Cortex in Fibromyalgia Syndrome), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04836325 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Transcranial Static Magnetic Field Stimulation Over the Primary Motor Cortex in Fibromyalgia Syndrome: A Randomized Controlled Pilot Study

TypeinterventionalSponsorUniversity of SevilleRan2021 to 2021Enrolled16ConditionsFibromyalgiaArmstranscranial static magnetic field stimulation (tSMS), Sham transcranial static magnetic field stimulation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Fioravante CaponeUnit of Neurology, Neurophysiology, and Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
Giovanni PellegrinoNeurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Francesco MotoleseUnit of Neurology, Neurophysiology, and Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
Mariagrazia RossiUnit of Neurology, Neurophysiology, and Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
Gabriella MusumeciUnit of Neurology, Neurophysiology, and Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
Vincenzo Di LazzaroUnit of Neurology, Neurophysiology, and Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
Università Campus Bio-Medico · ITMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral studies explored the biological effects of extremely low-frequency magnetic fields (ELF-MFs)

aimsTo evaluate whether ELF-MFs affect the propensity of the human cortex to undergo LTP-like plasticity.

methodsWe designed a randomized, single-blind, sham-controlled, cross-over study on 10 healthy subjects. Cortical plasticity was induced by intermittent theta burst stimulation (iTBS) before and after 45-min ELF-MFs (75 Hz; 1.8 mT) or sham exposure and was estimated by measuring the changes of motor evoked potentials (MEP) amplitude before and after each iTBS.

resultsNo adverse events were reported. No significant effects of ELF-MFs on cortical plasticity were found.

conclusionWhole-brain exposure to ELF-MFs (75 Hz; 1.8 mT) is safe and does not seem to significantly affect LTP-like plasticity in human motor cortex.

Indexed as

brain stimulationextremely low-frequency magnetic fieldslong-term potentiationlow frequencymagnetic fieldsplasticity

Identifiers

PMID32116603
PMCPMC7014826
OpenAlexW3005201507

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.