Evidence map›Paper›PMID 32116550›Full record

ArticleFrontiers in molecular neuroscience2020

Reduction of Silent Information Regulator 1 Activates Interleukin-33/ST2 Signaling and Contributes to Neuropathic Pain Induced by Spared Nerve Injury in Rats.

Yanyan Zeng, Yu Shi, Hongrui Zhan, Wei Liu, Guiyuan Cai, Haili Zhong, Yaping Wang, Shangjie Chen, Shimin Huang, Wen Wu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yanyan ZengDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yu ShiDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Hongrui ZhanDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wei LiuDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Guiyuan CaiDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Haili ZhongDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yaping WangDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shangjie ChenDepartment of Rehabilitation, Baoan Hospital, Southern Medical University, Shenzhen, China.
Shimin HuangDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wen WuDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Southern Medical University · CNZhujiang Hospital · CNSouthern Medical University Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging studies have demonstrated that interleukin (IL)-33 and its receptor ST2 act as key factors in inflammatory diseases. Moreover, accumulating evidence has suggested that cytokines, including tumor necrosis factor (TNF)-α and IL-1β, trigger an inflammatory cascade. SIRT1 has been shown to suppress the expression of inflammatory cytokines. However, the effects of SIRT1 on IL-33/ST2 signaling and initiation of the inflammatory cascade

Indexed as

IL-33inflammationneuropathic painSIRT1ST2

Identifiers

PMID32116550
PMCPMC7028692
OpenAlexW3005925839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.