ReviewFrontiers in neuroscience2020
The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- An Olfactory Piriform Cortex-Lateral Hypothalamus Neural Circuit Contributes to Linalool-Induced Analgesia.CNS neuroscience & therapeutics · 2026Article
- Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects.Nature communications · 2026Article
- Integrative analysis reveals the autoantibodyome neuroimmune signature of neurodegeneration.iScience · 2026Article
- Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions.International journal of molecular sciences · 2025Review
- Peroxisome, neuropeptide, and inflammation signaling pathways uniquely impacted by opioid exposure in the hypothalamus of males and females.Molecular and cellular neurosciences · 2025Article
- Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats.Addiction neuroscience · 2025Article
- LPS mediated neuronal c-Fos activation: whole-brain mapping, site and time effect in intoxicated mice.Toxicology research · 2025Article
- Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation.Nature communications · 2025Article
- Gut Microbiota in Women with Eating Disorders: A New Frontier in Pathophysiology and Treatment.Nutrients · 2025Review
- Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment.Molecular cancer · 2025Review
- Role of Hypothalamus in Acupuncture's Effects.Brain sciences · 2025Review
- Electroacupuncture Mitigates TRPV1 Overexpression in the Central Nervous System Associated with Fibromyalgia in Mice.Life (Basel, Switzerland) · 2024Article
- Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine.Neuropharmacology · 2024Article
- Hypothalamic neuronal outputs transmit sensorimotor signals at the onset of locomotor initiation.iScience · 2023Article
- Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus.eLife · 2023Article
- The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system.American journal of physiology. Cell physiology · 2023Review
- Uncovering the brain-wide pattern of synaptic input to vasopressin-expressing neurons in the paraventricular nucleus of the hypothalamus.The Journal of comparative neurology · 2023Article
- The waiting game: investigating the neurobiological transition from acute to persistent pain in adolescent rats.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The neural addiction of cancer.Nature reviews. Cancer · 2023Review
- Altered Brain Expression of DNA Methylation and Hydroxymethylation Epigenetic Enzymes in a Rat Model of Neuropathic Pain.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the regulation of inflammation and pain have been widely studied. The LH consists of a parasympathetic area that has connections with all the major parts of the brain. It controls the autonomic nervous system (ANS), regulates feeding behavior and wakeful cycles, and is a part of the reward system. In addition, it contains different types of neurons, most importantly the orexin neurons. These neurons, though few in number, perform critical functions such as inhibiting pain transmission and interfering with the reward system, feeding behavior and the hypothalamic pituitary axis (HPA). Recent evidence has identified a new role for orexin neurons in the modulation of pain transmission associated with several inflammatory diseases, including rheumatoid arthritis and ulcerative colitis. Here, we review recent findings on the various physiological functions of the LH with special emphasis on the orexin/receptor system and its role in mediating inflammatory pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.