Evidence map›Paper›PMID 32116524›Full record

ArticleFrontiers in neuroscience2020

Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke.

Dan Lu, Eric S Ho, Hongcheng Mai, Jiankun Zang, Yanfang Liu, Yufeng Li, Bing Yang, Yan Ding, Chi Kwan Tsang, Anding Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  20. Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dan LuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Eric S HoDepartment of Biology, Lafayette College, Easton, PA, United States.
Hongcheng MaiDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jiankun ZangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yanfang LiuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yufeng LiDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Bing YangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yan DingDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Chi Kwan TsangClinical Neuroscience Institute, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Anding XuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
First Affiliated Hospital of Jinan University · CNLafayette College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many hospitals lack facilities for accurate diagnosis of acute ischemic stroke (AIS). Circular RNA (circRNA) is highly expressed in the brain and is closely associated with stroke. In this study, we examined whether the blood-borne circRNAs could be promising candidates as adjunctive diagnostic biomarkers and their pathophysiological roles after stroke. We profiled the blood circRNA expression in mice subjected to experimental focal cerebral ischemia and validated the selected circRNAs in AIS patients. We demonstrated that 128, 198, and 789 circRNAs were significantly altered at 5 min, 3 h, and 24 h after ischemic stroke, respectively. Our bioinformatics analysis revealed that the circRNA-targeted genes were associated with the Hippo signaling pathway, extracellular matrix-receptor interaction, and fatty acid metabolism at 5 min, 3 h and 24 h after ischemic stroke, respectively. We verified that many of these circRNAs existed in the mouse brain. Furthermore, we found that most of the predicted circRNA-miRNA interactions apparently exhibited functional roles in terms of regulation of their target gene expression in the brain. We also verified that many of these mouse circRNAs were conserved in human. Finally, we found that circBBS2 and circPHKA2 were differentially expressed in the blood of AIS patients. These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke.

Indexed as

acute ischemic strokebioinformatics analysisbiomarkersbloodcerebral ischemiacircular RNA

Identifiers

PMID32116524
PMCPMC7015875
OpenAlexW3005530486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.