Evidence map›Paper›PMID 32116253›Full record

Observational studyJournal of Alzheimer's disease : JAD2020

Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer's Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years.

Arunima Kapoor, Robert Bartha, Sandra E Black, Michael Borrie, Morris Freedman, Fuqiang Gao, Nathan Herrmann, Jennifer Mandzia, Miracle Ozzoude, Joel Ramirez and 20 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Arunima KapoorSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Robert BarthaRobarts Research Institute and the Department of Medical Biophysics, the University of Western Ontario, London, ON, Canada.
Sandra E BlackSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Michael BorrieParkwood Institute, St. Joseph's Health Care Center, London, ON, Canada.
Morris FreedmanUniversity of Toronto, Toronto, ON, Canada.
Fuqiang GaoSunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Nathan HerrmannSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Jennifer MandziaWestern University, London, ON, Canada.
Miracle OzzoudeSunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Joel RamirezSunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Christopher J M ScottSunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Sean SymonsSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Corinne E FischerKeenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St. Michaels Hospital, Toronto, ON, Canada.
Andrew FrankElisabeth Bruyere Hospital, Ottawa, ON, Canada.
Dallas SeitzDepartment of Psychiatry and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Michael Uri WolfUniversity of Toronto, Toronto, ON, Canada.
Nicolaas Paul L G VerhoeffUniversity of Toronto, Toronto, ON, Canada.
Gary NaglieUniversity of Toronto, Toronto, ON, Canada.
William ReichmanUniversity of Toronto, Toronto, ON, Canada.
Mario MasellisSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Sara B MitchellSunnybrook Health Sciences Centre, Toronto, ON, Canada.
David F Tang-WaiUniversity of Toronto, Toronto, ON, Canada.
Maria Carmela TartagliaUniversity of Toronto, Toronto, ON, Canada.
Sanjeev KumarUniversity of Toronto, Toronto, ON, Canada.
Bruce G PollockUniversity of Toronto, Toronto, ON, Canada.
Tarek K RajjiUniversity of Toronto, Toronto, ON, Canada.
Elizabeth FingerParkwood Institute, St. Joseph's Health Care Center, London, ON, Canada.
Stephen H PasternakRobarts Research Institute and the Department of Medical Biophysics, the University of Western Ontario, London, ON, Canada.
ONDRI Investigators
Richard H SwartzSunnybrook Health Sciences Centre, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveStructural brain magnetic resonance imaging (MRI) is not mandatory in Alzheimer's disease (AD) research or clinical guidelines. We aimed to explore the use of structural brain MRI in AD/mild cognitive impairment (MCI) trials over the past 10 years and determine the frequency with which inclusion of standardized structural MRI acquisitions detects comorbid vascular and non-vascular pathologies.

methodsWe systematically searched ClinicalTrials.gov for AD clinical trials to determine their neuroimaging criteria and then used data from an AD/MCI cohort who underwent standardized MRI protocols, to determine type and incidence of clinically relevant comorbid pathologies.

resultsOf 210 AD clinical trials, 105 (50%) included structural brain imaging in their eligibility criteria. Only 58 (27.6%) required MRI. 16,479 of 53,755 (30.7%) AD participants were in trials requiring MRI. In the observational AD/MCI cohort, 141 patients met clinical criteria; 22 (15.6%) had relevant MRI findings, of which 15 (10.6%) were exclusionary for the study. DISCUSSION: In AD clinical trials over the last 10 years, over two-thirds of participants could have been enrolled without brain MRI and half without even a brain CT. In a study sample, relevant comorbid pathology was found in 15% of participants, despite careful screening. Standardized structural MRI should be incorporated into NIA-AA diagnostic guidelines (when available) and research frameworks routinely to reduce diagnostic heterogeneity.

Indexed as

ComorbidityAgedAged, 80 and overAlzheimer DiseaseBrainClinical Trials as TopicCognitive DysfunctionCohort StudiesDementia, VascularDiagnosis, DifferentialFemaleHumansIncidenceMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID32116253
PMCPMC7242844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.