Evidence map›Paper›PMID 32116194›Full record

ReviewCurrent neuropharmacology2020

The e-Psychonauts' 'Spiced' World; Assessment of the Synthetic Cannabinoids' Information Available Online.

Caroline Zangani, Fabrizio Schifano, Flavia Napoletano, Davide Arillotta, Liam Gilgar, Amira Guirguis, John M Corkery, Orsola Gambini, Alessandro Vento

Abstract readReview
In one paragraph

Review in Current neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Novel ΔChemical research in toxicology · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caroline ZanganiDepartment of Health Sciences, University of Milan, Milan, Italy.
Fabrizio SchifanoPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Flavia NapoletanoEast London Foundation Trust (ELFT), Homerton University Hospital, London, United Kingdom.
Davide ArillottaDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.
Liam GilgarGabalfa Clinic, Cardiff and Vale NHS Health Board, Cardiff, United Kingdom.
Amira GuirguisSwansea University Medical School, Institute of Life Sciences, Swansea, United Kingdom.
John M CorkeryPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Orsola GambiniDepartment of Health Sciences, University of Milan, Milan, Italy.
Alessandro VentoDepartment of Mental Health, School of psychology, G. Marconi, Telematic University, Rome, Italy. ASL Roma 2, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA wide range of novel psychoactive substances (NPS) is regularly searched and discussed online by web-based drug enthusiasts (i.e. the e-psychonauts). Among NPS, the range of synthetic cannabinoids (SC; 'Spice') currently represents a challenge for governments and clinicians.

methodsUsing a web crawler (i.e. the NPS.Finder®), the present study aimed at assessing psychonauts' fora/platforms to better understand the online mentions of SC.

resultsThe open-web crawling/navigating software identified here some 1,103 synthetic cannabinoids. Of these, 863 molecules were not listed in either the international or the European NPS databases.

conclusionA web crawling approach helped here in identifying a large range of unknown SC likely to possess a misuse potential. Most of these novel/emerging molecules are still relatively unknown. This is a reason for concern; each of these analogues potentially presents different toxicodynamic profiles and there is a lack of docking, preclinical, and clinical observations. Strengthening multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better assessing SC-associated public health risks.

Indexed as

CannabinoidsInternetHumansIllicit DrugsSocial MediaSocial NetworkingCannabinoidsIllicit Drugsnew psychoactive substancesNPSPsychonautssynthetic cannabinoidsweb crawling

Identifiers

PMID32116194
PMCPMC7709145

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.