Evidence map›Paper›PMID 32116132›Full record

ArticleRNA biology2020

Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs.

Yasutoshi Akiyama, Prakash Kharel, Takaaki Abe, Paul Anderson, Pavel Ivanov

Open access · greenAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  7. BeyondChemical reviews · 2025
    Review
  8. Article
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  10. A Novel tsRNA, mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  11. Review
  12. Review
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  16. Article
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  18. Article
  19. RTCB Complex Regulates Stress-Induced tRNA Cleavage.International journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yasutoshi AkiyamaDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital , Boston, MA, USA.
Prakash KharelDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital , Boston, MA, USA.ORCID 0000-0003-3886-2311
Takaaki AbeDepartment of Medical Science, Tohoku University Graduate School of Biomedical Engineering , Sendai, Japan.
Paul AndersonDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital , Boston, MA, USA.
Pavel IvanovDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital , Boston, MA, USA.ORCID 0000-0002-7986-7760
Brigham and Women's Hospital · USTohoku University · JP

Funding

Cellular Stress Response MechanismsR35GM126901 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2018 to 2022
$2.9M
Biology of RNA G-quadruplexesR01GM126150 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2019 to 2023
$1.9M
tRNA-derived stress-induced RNAs and translational controlR01GM146997 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2022 to 2025
$1.6M
NIGMS NIH HHS R01 GM126150NIGMS NIH HHS R01 GM146997NIGMS NIH HHS R35 GM126901
6 · The paper itself

Abstract

Recent transcriptome-wide studies have identified a diverse pool of transfer RNA (tRNA)-derived RNAs or tRNA-derived fragments (tRFs). Some of these RNAs have been demonstrated to be functional and involved in multiple biological processes ranging from the regulation of gene expression to transgenerational epigenetic inheritance. Post-transcriptional maturation of tRNAs includes various processing events including extensive decoration by various RNA modifications, which are required for correct tRNA folding and stability. Moreover, tRNA modifications determine the pattern and specificity of tRNA cleavage. The major drawbacks of many studies in the field of tRFs are that most of them used synthetic RNAs that closely mimic endogenous tRFs in their sequence, yet lack RNA modification that is found

Indexed as

Nucleic Acid ConformationCell LineEndoribonucleasesG-QuadruplexesHumansRNA Processing, Post-TranscriptionalRNA, TransferRNA, UntranslatedStress, PhysiologicalStructure-Activity RelationshipEndoribonucleasesRNA, TransferRNA, UntranslatedangiogeninribonucleasetRNAtRNA-derived stress-induced RNAstRNA fragments

Identifiers

PMID32116132
PMCPMC7549717
OpenAlexW3008851099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.