Evidence map›Paper›PMID 32115913›Full record

ArticleJournal of Zhejiang University. Science. B

CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord.

Cheng-Ming Ni, Bing-Yu Ling, Xiang Xu, He-Ping Sun, Hui Jin, Yu-Qiu Zhang, Hong Cao, Lan Xu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Chemokines and Pain in the Trigeminal System.Frontiers in pain research (Lausanne, Switzerland) · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Cheng-Ming NiDepartment of Endocrinology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Bing-Yu LingDepartment of Emergency, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou 225001, China.
Xiang XuDepartment of Endocrinology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
He-Ping SunDepartment of Endocrinology, the Affiliated Kunshan First People's Hospital of Jiangsu University, Kunshan 215300, China.
Hui JinDepartment of Endocrinology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Yu-Qiu ZhangDepartment of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Hong CaoDepartment of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Lan XuDepartment of Endocrinology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Wuxi People's Hospital · CNFudan University · CNJiangsu University · CNNorthern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA's underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014).

Indexed as

AnimalsChemokine CX3CL1CX3C Chemokine Receptor 1Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetic NeuropathiesHyperalgesiaMiceMice, Inbred C57BLSpinal CordStreptozocinChemokine CX3CL1CX3C Chemokine Receptor 1Cx3cl1 protein, mouseCx3cr1 protein, mouseStreptozocinP2X7 receptor (P2X7R); Mechanical allodynia; Streptozotocin; Diabetic mice

Identifiers

PMID32115913
PMCPMC7076343
OpenAlexW3005538515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.