ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2020
Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of severe asthma in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Risk factors for asthma exacerbations.The journal of allergy and clinical immunology. Global · 2025Article
- Features of children with critical asthma hospitalized in a pediatric intensive care unit: Results from the ICU-3A study.Pediatric pulmonology · 2025Article
- Risk factors for hospitalization in subspecialty patients with severe persistent asthma.Respiratory medicine · 2024Article
- Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain.Journal of clinical medicine · 2024Article
- Continuity of primary care and avoidable hospitalization in a young population with asthma: a population-based cohort study.Scientific reports · 2024Article
- Objective monitoring tools for improved management of childhood asthma.Respiratory research · 2024Review
- Beyond the Metabolic Syndrome: Non-Obvious Complications of Obesity in Children.Children (Basel, Switzerland) · 2023Review
- Burden of paediatric hospitalisations to the health care system, child and family: a systematic review of Australian studies (1990-2022).The Lancet regional health. Western Pacific · 2023Article
- Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.The Journal of allergy and clinical immunology · 2023Article
- Burden and unmet need for specialist care in poorly controlled and severe childhood asthma in a Danish nationwide cohort.Respiratory research · 2023Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort.ERJ open research · 2023Article
- Comment on "Evaluation of treatment of the exacerbation of asthma and wheezing in a pediatric emergency department".Revista da Associacao Medica Brasileira (1992) · 2023Article
- Article
- Short-acting βPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Past asthma exacerbation in children predicting future exacerbation: a systematic review.ERJ open research · 2022Article
- Sex differences in the relationship of sleep-disordered breathing and asthma control among children with severe asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Article
- Obesity Is Associated with Sustained Symptomatology and Unique Inflammatory Features in Children with Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- Viral Infection and Respiratory Exacerbation in Children: Results from a Local German Pediatric Exacerbation Cohort.Viruses · 2022Article
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma.
methodsAsthma patients 5-17 years old with ≥1 year of follow-up were identified in six European electronic databases from the Netherlands, Italy, the UK, Denmark and Spain in 2008-2013. Asthma was defined as ≥1 asthma-specific disease code within 3 months of prescriptions/dispensing of asthma medication. Severe asthma was defined as high-dosed inhaled corticosteroids plus a second controller. SAE was defined by systemic corticosteroids, emergency department visit and/or hospitalization all for reason of asthma. Risk factors for SAE were estimated by Poisson regression analyses.
resultsThe cohort consisted of 212 060 paediatric asthma patients contributing to 678 625 patient-years (PY). SAE rates ranged between 17 and 198/1000 PY and were higher in severe asthma and highest in severe asthma patients with a history of exacerbations. Prior SAE (incidence rate ratio 3-45) and younger age increased the SAE risk in all countries, whereas obesity, atopy and GERD were a risk factor in some but not all countries. Rehospitalization rates were up to 79% within 1 year.
conclusionsIn a real-world setting, SAE rates were highest in children with severe asthma with a history of exacerbations. Many severe asthma patients were rehospitalized within 1 year. Asthma management focusing on prevention of SAE is important to reduce the burden of asthma.
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