SynthesisReviews in endocrine & metabolic disorders2020
Clinical features, diagnosis and treatment of Paget's disease of bone in mainland China: A systematic review.
Synthesis in Reviews in endocrine & metabolic disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Radiological impact of oral bisphosphonate use on polyostotic Paget's disease of bone over a 2 year period.Radiology case reports · 2024Article
- Update on the pathogenesis and genetics of Paget's disease of bone.Frontiers in cell and developmental biology · 2022Review
- Clinical and demographic aspects of Paget disease of bone: A multicentric study from Turkey.European journal of rheumatology · 2021Article
- Paget's disease of bone: Report of 11 cases.World journal of clinical cases · 2021Article
- Paget's Disease of Bone in Patients under 40 Years: Two case reports and review of the literature.Sultan Qaboos University medical journal · 2021Review
- Paget's Disease of Bone in Tunisia: A Study of 69 Patients.Indian journal of endocrinology and metabolismArticle
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Authors and funding
9 authors.
Funding
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Abstract
Paget's disease of bone (PDB) is a metabolic bone disease with distinct geographical and ethnic differences in its pathogenesis. In this study, we aimed to retrospectively analyze the clinical features and the status of diagnosis and treatment of PDB in mainland China to improve the clinician's understanding of this disease. For this purpose, we conducted a systematic review of 118 articles, including a total of 332 patients with PDB. The results showed that the onset age of PDB in mainland China was 46-60 years. The number of male patients in most age groups was slightly higher than that of female patients, but there was no statistical difference (p > 0.05). The gender ratio (male to female) of PDB in mainland China was significantly different from that in Japan (p < 0.05), but not from that in the USA (p > 0.05). The clinical manifestations of PDB patients in mainland China mainly included ostealgia, bone malformation, hearing loss, and fracture, and bisphosphonate was used as the main treatment drug. These findings were similar to those in Japan, UK, and USA. Total alkaline phosphatase (TALP) level was elevated in about 89.7% of patients, and no correlation between TALP level and ostealgia was observed (p > 0.05). In addition, no difference in TALP level between males and females in each group was observed (p > 0.05).
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