Evidence map›Paper›PMID 32115417›Full record

ArticleAJNR. American journal of neuroradiology2020

Gadolinium Enhancement of the Aneurysm Wall in Extracranial Carotid Artery Aneurysms.

C J H C M van Laarhoven, M L Rots, V E C Pourier, N K N Jorritsma, T Leiner, J Hendrikse, M D I Vergouwen, G J de Borst

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05828576 (Seeking the Link Between Extracranial Carotid Artery Aneurysms and Small Vessel Disease), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05828576 unknown statusnot on this mapstarted 2023, after this paper: background citation

Seeking the Link Between Extracranial Carotid Artery Aneurysms and Small Vessel Disease

TypeobservationalSponsorUMC UtrechtRan2023 to 2025Enrolled50ConditionsExtracranial Carotid Artery AneurysmArmsMRI
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Black-Blood Contrast in Cardiovascular MRI.Journal of magnetic resonance imaging : JMRI · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

C J H C M van LaarhovenFrom the Departments of Vascular Surgery (C.J.H.C.M.v.L., M.L.R., V.E.C.P., N.K.N.J., G.J.d.B.).ORCID 0000-0002-8817-7315
M L RotsFrom the Departments of Vascular Surgery (C.J.H.C.M.v.L., M.L.R., V.E.C.P., N.K.N.J., G.J.d.B.).ORCID 0000-0002-3751-0376
V E C PourierFrom the Departments of Vascular Surgery (C.J.H.C.M.v.L., M.L.R., V.E.C.P., N.K.N.J., G.J.d.B.).ORCID 0000-0003-4766-8289
N K N JorritsmaFrom the Departments of Vascular Surgery (C.J.H.C.M.v.L., M.L.R., V.E.C.P., N.K.N.J., G.J.d.B.).ORCID 0000-0003-4583-0051
T LeinerRadiology (T.L., J.H.).ORCID 0000-0003-1885-5499
J HendrikseRadiology (T.L., J.H.).ORCID 0000-0001-6384-6140
M D I VergouwenUMC Utrecht Brain Center (M.D.I.V.), Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-6823-1628
G J de BorstFrom the Departments of Vascular Surgery (C.J.H.C.M.v.L., M.L.R., V.E.C.P., N.K.N.J., G.J.d.B.) g.j.deborst-2@umcutrecht.nl.ORCID 0000-0002-1389-4141
United States Nuclear Regulatory Commission · USResearch Institute of Radiology · BYUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe natural history and optimal treatment of extracranial carotid artery aneurysms are unknown. Gadolinium enhancement of the aneurysm wall may reflect aneurysm wall inflammation and instability. In this study, we investigated the feasibility of extracranial carotid artery aneurysm wall imaging and explored a potential relationship of aneurysm wall enhancement with aneurysm growth and the presence of (silent) brain infarcts and white matter lesions. MATERIALS AND

methodsFourteen conservatively treated patients with 15 asymptomatic extracranial carotid artery aneurysms underwent gadolinium-enhanced 3T MR imaging at 2 time points with a 12-month interval. Primary outcome was growth of the aneurysm sac (≥2.0 mm); secondary outcomes were the presence of (silent) brain infarcts and white matter lesions at baseline and follow-up. MR images were reviewed by 2 independent observers, and inter- and intraobserver reproducibility was assessed.

resultsSeven (50%) patients were men; the median age was 55 years (range, 40-69 years). Eleven extracranial carotid artery aneurysms (73%) were saccular (median size, 11 mm; range, 5.0-38.5 mm), and 4 were fusiform (median size, 21.5 mm; range, 10.0-40.0 mm). Eleven of 15 aneurysms (73%) exhibited gadolinium enhancement at baseline. Four aneurysms (27%) showed growth at follow-up imaging, 2 gadolinium-positive (+) and 2 gadolinium-negative (-) (

conclusionsIn this explorative study, we demonstrated that extracranial carotid artery aneurysm wall imaging was feasible. Future well-powered studies are needed to investigate whether extracranial carotid artery aneurysm gadolinium enhancement predicts aneurysm growth and thromboembolic complications.

Indexed as

AdultAgedAneurysmBrain InfarctionCarotid ArteriesCarotid Artery DiseasesContrast MediaFemaleGadoliniumHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsContrast MediaGadolinium

Identifiers

PMID32115417
PMCPMC7077910
OpenAlexW3008127307

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.