Evidence map›Paper›PMID 32114984›Full record

SynthesisGenome medicine2020

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Simon Kebede Merid, Alexei Novoloaca, Gemma C Sharp, Leanne K Küpers, Alvin T Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin and 83 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genome medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 11 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 11 syntheses or guidelines pooled it, 148 citations in OpenAlex.

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  15. DNA Methylation ofBiological research for nursing · 2026
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

93 authors at 20 institutions in 15 countries.

Simon Kebede MeridInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Alexei NovoloacaEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Gemma C SharpMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Leanne K KüpersPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Alvin T KhoComputational Health Informatics Program, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Ritu RoyComputational Biology And Informatics, University of California, San Francisco, San Francisco, CA, USA.
Lu GaoDepartment of Preventive Medicine, University of Southern California, Los Angeles, USA.
Isabella Annesi-MaesanoSorbonne Université and INSERM, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Saint-Antoine Medical School, Paris, France.
Pooja JainNIHR-Health Protection Research Unit, Respiratory Infections and Immunity, Imperial College London, London, UK.
Michelle PlusquinNIHR-Health Protection Research Unit, Respiratory Infections and Immunity, Imperial College London, London, UK.
Manolis KogevinasISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Catherine AllardCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Florianne O VehmeijerThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nabila KazmiMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Lucas A SalasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, USA.
Faisal I RezwanSchool of Water, Energy and Environment, Cranfield University, Cranfield, Bedfordshire, MK43 0AL, UK.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, USA.
Sylvain SebertCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Darina CzamaraDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Phillip E MeltonSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, Australia.
Debbie A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Carrie V BretonDepartment of Preventive Medicine, University of Southern California, Los Angeles, USA.
Karen HuenChildren's Environmental Health Laboratory, University of California, Berkeley, Berkeley, CA, USA.
Nour BaizSorbonne Université and INSERM, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Saint-Antoine Medical School, Paris, France.
Luigi GagliardiDivision of Neonatology and Pediatrics, Ospedale Versilia, Viareggio, AUSL Toscana Nord Ovest, Pisa, Italy.
Tim S NawrotNIHR-Health Protection Research Unit, Respiratory Infections and Immunity, Imperial College London, London, UK.
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Patrice PerronCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Liesbeth DuijtsThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ellen Aagaard NohrResearch Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Mariona BustamanteISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Susan L EwartCollege of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, USA.
Shanshan ZhaoDepartment of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, Durham, NC, USA.
Christian M PageNorwegian Institute of Public Health, Oslo, Norway.
Zdenko HercegEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Marjo-Riitta JarvelinCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
Denise AndersonTelethon Kids Institute, University of Western Australia, Perth, Australia.
Priyadarshini KachrooChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Caroline L ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), University of California, Berkeley, Berkeley, CA, USA.
Munawar Hussain SoomroSorbonne Université and INSERM, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Saint-Antoine Medical School, Paris, France.
Paolo VineisMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Luigi BouchardCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Vincent W JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Thorkild I A SørensenMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Martine VrijheidISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
S Hasan ArshadClinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
John W HollowayHuman Development & Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Siri E HåbergNorwegian Institute of Public Health, Oslo, Norway.
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.
Terence DwyerNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Dawn L DeMeoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
John NewnhamFaculty of Health and Medical Sciences, UWA Medical School, University of Western Australia, Perth, Australia.
Kelan G TantisiraChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Inger KullDepartment of Clinical Sciences and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Joseph L WiemelsCenter for Genetic Epidemiology, University of Southern California, Los Angeles, USA.
Barbara HeudeINSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Research Team on Early life Origins of Health (EarOH), Paris Descartes University, Paris, France.
Jordi SunyerISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Wenche NystadNorwegian Institute of Public Health, Oslo, Norway.
Monica C Munthe-KaasNorwegian Institute of Public Health, Oslo, Norway.
Katri RäikkönenNorwegian Institute of Public Health, Oslo, Norway.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Rae-Chi HuangTelethon Kids Institute, University of Western Australia, Perth, Australia.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Josep Maria AntóISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Jean BousquetUniversity Hospital, Montpellier, France.
Ashish KumarInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Cilla SöderhällDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Andres CardenasDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Olena GruzievaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Cheng-Jian XuUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute Groningen, Groningen, The Netherlands.
Sarah E ReeseDepartment of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, Durham, NC, USA.
Juha KereDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Petter BrodinDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Olivia SolomonChildren's Environmental Health Laboratory, University of California, Berkeley, Berkeley, CA, USA.
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Nina HollandChildren's Environmental Health Laboratory, University of California, Berkeley, Berkeley, CA, USA.
Akram GhantousEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Marie-France HivertCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute Groningen, Groningen, The Netherlands.
Stephanie J LondonDepartment of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, Durham, NC, USA.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. erik.melen@ki.se.ORCID 0000-0002-8248-0663
Karolinska Institutet · SEUniversity Medical Center Groningen · NLNorwegian Institute of Public Health · NOUniversitat Pompeu Fabra · ESBrigham and Women's Hospital · USErasmus MC · NLUniversity of Bristol · GBCentre international de recherche sur le cancer · FRHarvard University · USInserm · FRNational Institutes of Health · USUniversité de Sherbrooke · CAUniversity of California, Berkeley · USUniversity of Southern California · USKarolinska University Hospital · SEThe Kids Research Institute Australia · AUUCL Biomedical Research Centre · GBUniversity of Memphis · USAzienda Usl Toscana Centro · ITBentley University · US

Funding

Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2016 to 2020
$12.6M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
MICRORNAS AND EARLY LIFE EXPOSURES IN THE DEVELOPMENTAL ORIGIN OF ASTHMAR01HL125734 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SHARMA, SUNITA · 2016 to 2020
$3.5M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2M
DISEASE AND HEALTH: ASTHMA RESILIENCE THROUGH MICRORNA ATTRIBUTES (DHARMA)R01HL129935 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2017
$1.4M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013/2Medical Research Council MR/S009310/1Medical Research Council MR/S019669/1NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL125734NHLBI NIH HHS R01 HL127332NHLBI NIH HHS R01 HL129935NIDDK NIH HHS R01 DK103246World Health Organization 001
6 · The paper itself

Abstract

backgroundPreterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children.

methodsWe performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung.

resultsWe identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10

conclusionsWe identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.

Indexed as

DNA MethylationEpigenomeAdolescentChildChild, PreschoolDNAFemaleFetal DevelopmentGenetic LociHumansInfant, NewbornInfant, PrematureMalePremature BirthDNADevelopmentEpigeneticsGestational agePreterm birthTranscriptomics

Identifiers

PMID32114984
PMCPMC7050134
OpenAlexW3009067006

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.