Evidence map›Paper›PMID 32114890›Full record

ArticleJournal of the American Heart Association2020

Socioeconomic Factors, Secondary Prevention Medication, and Long-Term Survival After Coronary Artery Bypass Grafting: A Population-Based Cohort Study From the SWEDEHEART Registry.

Susanne J Nielsen, Martin Karlsson, Erik Björklund, Andreas Martinsson, Emma C Hansson, Carl Johan Malm, Aldina Pivodic, Anders Jeppsson

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06995586 (The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06995586 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.

TypeinterventionalSponsorNicosia General HospitalRan2026 to 2028Enrolled108ConditionsCardio-pulmonary Bypass, Cardiovascular Diseases, Omega-3 Polyunsaturated Fatty Acids, Omega-3 SupplementationArmsVitamin C, Omega 3 PUFA (EPO/DHA), Lignin, Lactulose
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Socioeconomic factors and long-term mortality risk after surgical aortic valve replacement.International journal of cardiology. Cardiovascular risk and prevention · 2023
    Article
  4. The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2020.Journal of cardiothoracic and vascular anesthesia · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Current Concepts in the Prevention of Perioperative Myocardial Injury.Translational perioperative and pain medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Susanne J NielsenDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Martin KarlssonDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Erik BjörklundDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Andreas MartinssonDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Emma C HanssonDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Carl Johan MalmDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Aldina PivodicStatistiska Konsultgruppen Gothenburg Sweden.
Anders JeppssonDepartment of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.
Sahlgrenska University Hospital · SESkaraborg Hospital · SESödra Älvsborg Hospital · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Low income and short education have been found to be independently associated with inferior survival after coronary artery bypass grafting (CABG), whereas the use of secondary prevention medications is associated with improved survival. We investigated whether underusage of secondary prevention medications contributes to the inferior long-term survival in CABG patients with a low income and short education. Methods and Results Patients who underwent CABG in Sweden between 2006 to 2015 and survived at least 6 months after discharge (n=28 448) were included in a population-based cohort study. Individual patient data from 5 national registries, including the SWEDEHEART (Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies) registry, covering dispensing of secondary prevention medications (statins, platelet inhibitors, β-blockers, and RAAS inhibitors), socioeconomic factors, patient characteristics, comorbidity, and long-term mortaity were merged. All-cause mortality risk was estimated using multivariable Cox regression models adjusted for patient characteristics, baseline comorbidities, time-updated secondary prevention medications, and socioeconomic status. Long-term mortality was higher in patients with a low income and short education. Statins and platelet inhibitors were dispensed less often to patients with a low income, both at baseline and after 8 years. The decline in dispensing over time was steeper for low-income patients. Short education was not associated with reduced dispensing of any secondary prevention medication. Use of statins (adjusted hazard ratio=0.57 [95% CI, 0.53-0.61]), RAAS inhibitors (adjusted hazard ratio=0.78 [0.73-0.84]), and platelet inhibitors (adjusted hazard ratio=0.74 [0.68-0.80]) were associated with reduced long-term mortality irrespective of socioeconomic status. Conclusions Secondary prevention medications are dispensed less often after CABG to patients with low income. Underusage of secondary prevention medications after CABG is associated with increased mortality risk independently of income and extent of education.

Indexed as

Coronary Artery BypassSecondary PreventionAdrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsCardiovascular AgentsCohort StudiesCoronary Artery DiseaseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPlatelet Aggregation InhibitorsPractice Patterns, Physicians'Socioeconomic FactorsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsCardiovascular AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation Inhibitorscoronary artery bypass graftingmedicationmortalitysecondary preventionsocioeconomic status

Identifiers

PMID32114890
PMCPMC7335537
OpenAlexW3010196921

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.