Evidence map›Paper›PMID 32114880›Full record

ArticleEpigenetics2020

A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML.

Michael A Koldobskiy, Jordi Abante, Garrett Jenkinson, Elisabet Pujadas, Ashley Tetens, Feifei Zhao, Rakel Tryggvadottir, Adrian Idrizi, Andreas Reinisch, Ravindra Majeti and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Michael A KoldobskiyCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Jordi AbanteWhitaker Biomedical Engineering Institute, Johns Hopkins University , Baltimore, MD, USA.ORCID 0000-0003-4137-2858
Garrett JenkinsonCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.ORCID 0000-0003-2548-098X
Elisabet PujadasCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.ORCID 0000-0003-4795-7945
Ashley TetensCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Feifei ZhaoDepartment of Medicine, Division of Hematology, Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine , Stanford, CA, USA.
Rakel TryggvadottirCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Adrian IdriziCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Andreas ReinischDepartment of Medicine, Division of Hematology, Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine , Stanford, CA, USA.
Ravindra MajetiDepartment of Medicine, Division of Hematology, Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine , Stanford, CA, USA.ORCID 0000-0002-5814-0984
John GoutsiasWhitaker Biomedical Engineering Institute, Johns Hopkins University , Baltimore, MD, USA.
Andrew P FeinbergCenter for Epigenetics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Johns Hopkins University · USStanford University · USMedical University of Graz · AT

Funding

MOLECULAR PATHOLOGY OF WILMS TUMOR RELATED GENES 11PR01CA054358 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREW P. FEINBERG · 1991 to 2026
$5.5M
Pre-Leukemic Hematopoietic Stem Cells and Clonal Evolution in Human AMLR01CA188055 · NCI · STANFORD UNIVERSITY · PI MAJETI, RAVINDRA · 2014 to 2018
$1.6M
RADIOTHERAPY EFFECTS ON BRAIN FUNCTIONING IN ADULTSR01CA065438 · NCI · CHILDREN'S HOSPITAL OF PHILADELPHIA · PI ARMSTRONG, CAROL L. · 1997 to 2001
$987k
NCI NIH HHS R01 CA054358NCI NIH HHS R01 CA065438NCI NIH HHS R01 CA188055
6 · The paper itself

Abstract

Translocations of the

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticEpigenesis, GeneticHistone-Lysine N-MethyltransferaseHumansLeukemia, Biphenotypic, AcuteLeukemia, Myeloid, AcuteMyeloid-Lymphoid Leukemia ProteinTranscriptomeTranslocation, GeneticHistone-Lysine N-MethyltransferaseKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinDNA methylationDNA methylation stochasticityLeukaemia

Identifiers

PMID32114880
PMCPMC7518694
OpenAlexW3007109941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.