ReviewThe American journal of psychiatry2020
Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders.
Review in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms.The Cochrane database of systematic reviews · 2024Pooled it
- Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).The Cochrane database of systematic reviews · 2022Pooled it
- Effectiveness of Finnish SISU training in enhancing prehospital personnels' work performance: A randomised controlled pilot study.BMC emergency medicine · 2025Trial
- Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear.The international journal of neuropsychopharmacology · 2022Trial
- Executive Functioning in Pediatric Anxiety and Its Relationship to Selective Serotonin Reuptake Inhibitor Treatment Response: A Double-Blind, Placebo-Controlled Trial.Journal of child and adolescent psychopharmacology · 2022Trial
- A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit.Neuroscience bulletin · 2026Article
- Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Top-down medial prefrontal cortex-to-hypothalamic paraventricular nucleus circuit regulates social avoidance and conditioned fear in male mice.Cell discovery · 2026Article
- Article
- Synaptic, cellular, and circuit mechanisms underlying sex differences in behaviors.Biology of sex differences · 2026Review
- Post-traumatic stress disorder.Nature reviews. Disease primers · 2026Review
- Acute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner.Psychopharmacology · 2026Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1.Biological psychiatry global open science · 2025Article
- Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.Science advances · 2025Article
- Causality Between Irritable Bowel Syndrome and Suicide Attempt: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Cholinergic signaling to CA1 astrocytes controls fear extinction.Science advances · 2025Article
- Resting-state functional connectivity in anxiety disorders: a multicenter fMRI study.Molecular psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Anxiety and fear-related disorders are common and disabling, and they significantly increase risk for suicide and other causes of morbidity and mortality. However, there is tremendous potential for translational neuroscience to advance our understanding of these disorders, leading to novel and powerful interventions and even to preventing their initial development. This overview examines the general circuits and processes thought to underlie fear and anxiety, along with the promise of translational research. It then examines some of the data-driven "next-generation" approaches that are needed for discovery and understanding but that do not always fit neatly into established models. From one perspective, these disorders offer among the most tractable problems in psychiatry, with a great deal of accumulated understanding, across species, of neurocircuit, behavioral, and, increasingly, genetic mechanisms, of how dysregulation of fear and threat processes contributes to anxiety-related disorders. One example is the progressively sophisticated understanding of how extinction underlies the exposure therapy component of cognitive-behavioral therapy approaches, which are ubiquitously used across anxiety and fear-related disorders. However, it is also critical to examine gaps in our understanding between reasonably well-replicated examples of successful translation, areas of significant deficits in knowledge, and the role of large-scale data-driven approaches in future progress and discovery. Although a tremendous amount of progress is still needed, translational approaches to understanding, treating, and even preventing anxiety and fear-related disorders offer great opportunities for successfully bridging neuroscience discovery to clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.