ArticleActa diabetologica2020
Genetic determinants of gestational diabetes mellitus: a case-control study in two independent populations.
Article in Acta diabetologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Association ofBiomolecules & biomedicine · 2025Pooled it
- Identification and Potential Clinical Utility of Common Genetic Variants in Gestational Diabetes among Chinese Pregnant Women.Diabetes & metabolism journal · 2025Pooled it
- Progression to type 2 diabetes mellitus after gestational diabetes mellitus diagnosed by IADPSG criteria: Systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis.Journal of diabetes research · 2021Pooled it
- Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet.Frontiers in endocrinology · 2022Trial
- Assessing individual genetic susceptibility to metabolic syndrome: interpretable machine learning method.Annals of medicine · 2025Article
- PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Maternal pre-pregnancy risks and postpartum consequences of gestational diabetes.Reproduction (Cambridge, England) · 2025Review
- Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes.World journal of clinical pediatrics · 2025Review
- The use of late preterm antenatal corticosteroids in women with gestational diabetes : a puzzle worth solving.BMC pregnancy and childbirth · 2024Article
- Article
- Genetic risk score to improve prediction and treatment in gestational diabetes mellitus.Frontiers in endocrinology · 2022Review
- Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus.Frontiers in physiology · 2022Review
- Melatonin Receptor 1B Genetic Variants on Susceptibility to Gestational Diabetes Mellitus: A Hospital-Based Case-Control Study in Wuhan, Central China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Construction of a novel miRNA regulatory network and identification of target genes in gestational diabetes mellitus by integrated analysis.Frontiers in genetics · 2022Article
- Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease.International journal of molecular sciences · 2021Review
- Genetic variants associated with beta-cell function and insulin sensitivity potentially influence bile acid metabolites and gestational diabetes mellitus in a Chinese population.BMJ open diabetes research & care · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic risk score (GRS) is more informative to identify the complicated associations between variants of genes and disease. Considering similar pathogenesis and shared genetic predispositions between gestational diabetes mellitus (GDM) and type 2 diabetes/obesity, we conducted this study to explore whether the GRS model integrating variants related to type 2 diabetes/obesity is also associated with GDM risk.
methodsA population-based case-control study that included 1429 subjects was conducted to investigate the association between the GRS model and GDM risk, which were analyzed employing stratified logistic regression analysis with the adjustment for age, BMI, parity and family history of diabetes.
resultsWe have screened 23 SNPs and further filtered six SNPs that were significantly associated with the risk of GDM: four risk SNPs (MTNR1B: rs10830963, rs1387153, rs2166706; MC4R: rs2229616) and two protective SNPs (MTNR1B: rs1447352 and rs4753426). The GRS model with a higher score indicated a higher genetic predisposition to develop GDM, especially in the highest quartile of GRS (all P < 0.001) and the strata of advanced maternal age (all P < 0.001) and obesity (all P = 0.005).
conclusionIn this study, six SNPs were explored and further identified to be associated with GDM risk, which suggested GRSs including these polymorphisms might participate in facilitating GDM risk. These findings offer the potential to improve our understanding of the etiology of GDM.
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