Evidence map›Paper›PMID 32114612›Full record

Trial reportAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2020

Decreasing Delirium Through Music: A Randomized Pilot Trial.

Sikandar H Khan, Chenjia Xu, Russell Purpura, Sana Durrani, Heidi Lindroth, Sophia Wang, Sujuan Gao, Annie Heiderscheit, Linda Chlan, Malaz Boustani and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Trial
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  11. Review
  12. Article
  13. The Neuropsychiatric Disturbances of Delirium: A Review of Syndromes and Their Treatment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Review
  14. Effect of music therapy on outcomes of critically ill patients.World journal of critical care medicine · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Live music in the intensive care unit - a beautiful experience.International journal of qualitative studies on health and well-being · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Sikandar H KhanSikandar H. Khan is an assistant professor, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, and a scientist, Center for Aging Research, Indiana University, Indianapolis, Indiana.
Chenjia XuChenjia Xu is a doctoral student.
Russell PurpuraRussell Purpura is an internal medicine resident, Department of Medicine, Indiana University School of Medicine.
Sana DurraniSana Durrani is a research associate, Center for Aging Research, Indiana University.
Heidi LindrothHeidi Lindroth is a T32 postdoctoral fellow, Center for Aging Research, Indiana University, and a postdoctoral fellow, Indiana University School of Nursing.
Sophia WangSophia Wang is an assistant professor, Department of Psychiatry, Indiana University School of Medicine.
Sujuan GaoSujuan Gao is a professor, Department of Biostatistics, Indiana University School of Medicine.
Annie HeiderscheitAnnie Heiderscheit is an associate professor of music and director of music therapy, Augsburg University, Minneapolis, Minnesota.
Linda ChlanLinda Chlan is a professor, Department of Nursing, and associate dean, Nursing Research Division, Mayo Clinic, Rochester, Minnesota.
Malaz BoustaniMalaz Boustani is a professor of medicine, Center for Aging Research, Indiana University, and a scientist, Center for Health Innovation and Implementation Science, Indianapolis, Indiana.
Babar A KhanBabar A. Khan is an associate professor, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, and a scientist, Center for Aging Research, Indiana University.
Indiana University · USIndiana University – Purdue University Indianapolis · USAugsburg University · USIndiana University Health · USIssues Research · USMayo Clinic · USNational Postdoctoral Association · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO · 1991 to 2020
$37.3M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly OrganizationsR01AG030618 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONNA Marie FICK, EDWARD R MARCANTONIO · 2008 to 2026
$7.9M
Brain Health Patient Safety Learning LaboratoryP30HS024384 · AHRQ · INDIANA UNIVERSITY INDIANAPOLIS · PI CALLAHAN, CHRISTOPHER M · 2015 to 2018
$3.8M
Duke University Molecular Imaging CenterR24CA092656 · NCI · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2001 to 2006
$3.7M
Decreasing Alzheimer's Disease and Related Dementias after Delirium-Exercise and Cognitive Training (DDD-ECT)R01AG055391 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KHAN, BABAR A · 2017 to 2021
$3.5M
Efficacy of self-management of sedative therapy by ventilated ICU patientsR01HL130881 · NHLBI · MAYO CLINIC ROCHESTER · PI CHLAN, LINDA L, TRACY, MARY FRANCES · 2016 to 2021
$3.2M
Mobile Critical Care Recovery Program (m-CCRP) for Acute Respiratory Failure (ARF) SurvivorsR01HL131730 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KHAN, BABAR A · 2017 to 2021
$3.2M
Indiana University Dementia Screening Trial: The IU CHOICE StudyR01AG040220 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BOUSTANI, MALAZ · 2012 to 2016
$2.8M
Pharmacological Management of DeliriumR01AG034205 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BOUSTANI, MALAZ · 2010 to 2014
$2.5M
Small Animal Imaging Resource ProgramU24CA092656 · NCI · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2007 to 2011
$2.2M
Indiana Clinical and Translational Sciences InstituteTL1TR001107 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$2.0M
AHRQ HHS P30 HS024384NCATS NIH HHS TL1 TR001107NCATS NIH HHS UL1 TR001108NCI NIH HHS R24 CA092656NCI NIH HHS U24 CA092656NHLBI NIH HHS R01 HL130881NHLBI NIH HHS R01 HL131730NIA NIH HHS K23 AG043476NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG030618NIA NIH HHS R01 AG034205NIA NIH HHS R01 AG040220NIA NIH HHS R01 AG055391NINR NIH HHS R01 NR009295
6 · The paper itself

Abstract

backgroundManagement of delirium in intensive care units is challenging because effective therapies are lacking. Music is a promising nonpharmacological intervention.

objectivesTo determine the feasibility and acceptability of personalized music (PM), slow-tempo music (STM), and attention control (AC) in patients receiving mechanical ventilation in an intensive care unit, and to estimate the effect of music on delirium.

methodsA randomized controlled trial was performed in an academic medical-surgical intensive care unit. After particular inclusion and exclusion criteria were applied, patients were randomized to groups listening to PM, relaxing STM, or an audiobook (AC group). Sessions lasted 1 hour and were given twice daily for up to 7 days. Patients wore noise-canceling headphones and used mp3 players to listen to their music/audiobook. Delirium and delirium severity were assessed twice daily by using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the CAM-ICU-7, respectively.

resultsOf the 1589 patients screened, 117 (7.4%) were eligible. Of those, 52 (44.4%) were randomized, with a recruitment rate of 5 patients per month. Adherence was higher in the groups listening to music (80% in the PM and STM groups vs 30% in the AC group; P = .01), and 80% of patients surveyed rated the music as enjoyable. The median number (interquartile range) of delirium/coma-free days by day 7 was 2 (1-6) for PM, 3 (1-6) for STM, and 2 (0-3) for AC (P = .32). Median delirium severity was 5.5 (1-7) for PM, 3.5 (0-7) for STM, and 4 (1-6.5) for AC (P = .78).

conclusionsMusic delivery is acceptable to patients and is feasible in intensive care units. Further research testing use of this promising intervention to reduce delirium is warranted.

Indexed as

Intensive Care UnitsAdolescentAdultAgedBlood PressureCritical IllnessDeliriumDiastoleFemaleHeart RateHumansMaleMiddle AgedMusic TherapyPilot ProjectsRespiration, Artificial

Identifiers

PMID32114612
PMCPMC7666845
OpenAlexW3009941211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.