ArticleHeart (British Cardiac Society)2020
Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.
Article in Heart (British Cardiac Society), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Cardiovascular disease in idiopathic pulmonary fibrosis: a systematic review and meta-analysis of observational studies.Frontiers in medicine · 2025Pooled it
- Clinical implications of coronary artery calcification in lung cancer screening populations with interstitial lung abnormalities: a retrospective cohort study.European radiology · 2026Article
- Care of the Patient with Interstitial Lung Disease Perioperatively.Current rheumatology reports · 2026Review
- PCSK6 and clinical outcomes in the Pulmonary Fibrosis Foundation Patient Registry.Respiratory research · 2026Article
- Non-specific ST-T abnormalities are associated with major adverse cardiovascular and cerebrovascular events (MACCE) in hospitalized systemic lupus erythematosus patients.BMC rheumatology · 2026Article
- Age-associated B-cells across the rheumatoid arthritis continuum: from early immunopathogenesis to comorbidities.Frontiers in aging · 2026Review
- Comorbidities' Effect on IPF: Pathogenesis and Management.Biomedicines · 2025Review
- Lung transplantation for interstitial lung disease.Breathe (Sheffield, England) · 2025Review
- Incidence and clinical impact of coronary artery disease confirmed by coronary CT angiography in patients with interstitial lung disease.BMC pulmonary medicine · 2025Article
- Correlation of Coronary Calcium Measured on Conventional Computed Tomography with Coronary Angiography Findings in Lung Transplant Patients.Tomography (Ann Arbor, Mich.) · 2025Article
- Editorial: Advances in understanding and managing systemic sclerosis-associated interstitial lung disease: bridging prognostic biomarkers to therapeutic innovations.Frontiers in medicine · 2025Article
- Article
- Deep learning to predict long-term mortality from plain chest X-ray in patients referred for suspected coronary artery disease.Journal of thoracic disease · 2024Article
- Risk of cardiovascular events following COVID-19 in people with and without pre-existing chronic respiratory disease.International journal of epidemiology · 2024Article
- A Step towards understanding coronary artery disease: a complication in idiopathic pulmonary fibrosis.BMJ open respiratory research · 2024Article
- Article
- Treatable traits: a comprehensive precision medicine approach in interstitial lung disease.The European respiratory journal · 2023Article
- Idiopathic pulmonary fibrosis is more strongly associated with coronary artery disease than chronic obstructive pulmonary disease.Respiratory medicine · 2023Article
- Investigating the efficacy of osimertinib and crizotinib in phase 3 clinical trials on anti-cancer treatment-induced cardiotoxicity: are real-world studies the way forward?Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2023Article
- Chronic rheumatologic disorders and cardiovascular disease risk in women.American heart journal plus : cardiology research and practice · 2023Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesDespite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing patients who may benefit from screening for these cardiovascular diseases from receiving it.
methodsA population-based cohort study used electronic patient records from the Clinical Practice Research Datalink and linked Hospital Episode Statistics to identify 68 572 patients (11 688 ILD exposed (mean follow-up: 3.8 years); 56 884 unexposed controls (mean follow-up: 4.0 years), with 349 067 person-years of follow-up. ILD-exposed patients (pulmonary sarcoidosis (PS) or idiopathic pulmonary fibrosis (PF)) were matched (by age, sex, registered general practice and available follow-up time) to patients without ILD or IHD/MI. Rates of incident MI and IHD were estimated. HRs were modelled using multivariable Cox proportional hazards regression accounting for potential confounders.
resultsILD was independently associated with IHD (HR 1.85, 95% CI 1.56 to 2.18) and MI (HR 1.74, 95% CI 1.44 to 2.11). In all disease categories, risk of both IHD and MI peaked between ages 60 and 69 years, except for the risk of MI in PS which was greatest <50 years. Men with PF were at greatest risk of IHD, while women with PF were at greatest risk of MI.
conclusionsILD, particularly PF, is independently associated with MI and IHD after adjustment for established cardiovascular risk factors. Our results suggest clinicians should prioritise targeted assessment of cardiovascular risk in patients with ILD, particularly those aged 60-69 years. Further research is needed to understand the impact of such an approach to risk management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.