Evidence map›Paper›PMID 32114334›Full record

ReviewCurrent opinion in microbiology2020

Harnessing the gut microbiome in the fight against anthelminthic drug resistance.

Thomas J Sharpton, Leigh Combrink, Holly K Arnold, Christopher A Gaulke, Michael Kent

Erratum issuedOpen access · hybridAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Impact of Ivermectin on the Gut Microbial Ecosystem.International journal of molecular sciences · 2023
    Article
  6. Nematocidal Activity of Ethanol and Aqueous Extracts ofJournal of parasitology research · 2023
    Article
  7. Article
  8. Review
  9. Molecules (Basel, Switzerland) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thomas J SharptonDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA; Department of Statistics, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: thomas.sharpton@oregonstate.edu.
Leigh CombrinkDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA; Department of Biomedical Sciences, Oregon State University, Corvallis, OR, 97331, USA.
Holly K ArnoldDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, 97331, USA.
Christopher A GaulkeDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA.
Michael KentDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA; Department of Biomedical Sciences, Oregon State University, Corvallis, OR, 97331, USA.
Oregon State University · US

Funding

Control of Diseases in Zebrafish Research FacilitiesR24OD010998 · OD · OREGON STATE UNIVERSITY · PI KENT, MICHAEL LAWRENCE · 2012 to 2021
$3.0M
Interactions between Gut Microbiome Natural Products and Intestinal HelminthsR21AI135641 · NIAID · OREGON STATE UNIVERSITY · PI KENT, MICHAEL LAWRENCE, SHARPTON, THOMAS JEFFERSON · 2018 to 2019
$404k
NIAID NIH HHS R21 AI135641NIH HHS R24 OD010998
6 · The paper itself

Abstract

Intestinal helminth parasites present major challenges to the welfare of humans and threaten the global food supply. While the discovery of anthelminthic drugs empowered our ability to offset these harms to society, the alarming rise of anthelminthic drug resistance mitigates contemporary efforts to treat and control intestinal helminthic infections. Fortunately, emerging research points to potential opportunities to combat anthelminthic drug resistance by harnessing the gut microbiome as a resource for discovering novel therapeutics and informing responsible drug administration. In this review, we highlight research that demonstrates this potential and provide rationale to support increased investment in efforts to uncover and translationally utilize knowledge about how the gut microbiome mediates intestinal helminthic infection and its outcomes.

Indexed as

Drug ResistanceGastrointestinal MicrobiomeAnimalsAnthelminticsHelminthiasisHelminthsHumansIntestinal Diseases, ParasiticAnthelmintics

Identifiers

PMID32114334
PMCPMC7722764
OpenAlexW3008963797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.