Evidence map›Paper›PMID 32114208›Full record

ArticlePsychiatry research2020

Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.

Martin Lundberg, Joanna M Biernacka, Catharina Lavebratt, Brooke Druliner, Euijung Ryu, Jennifer Geske, Colin Colby, Lisa Boardman, Mark Frye, Martin Schalling

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Review
  6. Article
  7. Review
  8. Article
  9. Epigenetic GrimAge acceleration and cognitive impairment in bipolar disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Martin LundbergDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address: emklundberg@outlook.com.
Joanna M BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Brooke DrulinerDepartment of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Euijung RyuDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Jennifer GeskeDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Colin ColbyDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Lisa BoardmanDepartment of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Mark FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Mayo Clinic in Florida · USMayo Clinic · USKarolinska University Hospital · SEKarolinska Institutet · SE

Funding

Individualizing colorectal cancer patient care using the host and tumor telomere phenotypeR01CA204013 · NCI · MAYO CLINIC ROCHESTER · PI BOARDMAN, LISA ALLYN · 2016 to 2020
$3.2M
NCI NIH HHS R01 CA204013
6 · The paper itself

Abstract

Bipolar disorder (BD) may be associated with accelerated cellular aging. However, previous studies on telomere length (TL), an important biomarker of cellular aging, have yielded mixed results in BD. We aimed to evaluate the hypothesis that BD is associated with telomere shortening and whether this is counteracted by long-term lithium treatment. We also sought to determine whether long-term lithium treatment is associated with increased expression of telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase. We determined TL and TERT expression in 100 BD I patients and 100 healthy controls. We also genotyped three single nucleotide polymorphisms associated with TL. TERT expression was significantly increased in BD I patients currently on lithium treatment. TERT expression was also significantly positively correlated with duration of lithium treatment in patients treated for 24 months or more. However, we did not find any significant effect of lithium treatment on TL. Neither did we find significant differences in TL between BD patients and controls. We suggest that long-term lithium treatment is associated with an increase in the expression of TERT. We hypothesize that an increase in TERT expression may contribute to lithium's mood stabilizing and neuroprotective properties by improving mitochondrial function and decreasing oxidative stress.

Indexed as

AdultAgingAntimanic AgentsBipolar DisorderCellular SenescenceFemaleHumansLithiumLithium CompoundsMaleMiddle AgedMitochondriaOxidative StressPolymorphism, Single NucleotideReal-Time Polymerase Chain ReactionTelomeraseAntimanic AgentsLithiumLithium CompoundsTelomeraseTERT protein, humanAffective disorderAgingMitochondriaOxidative stressTelomereTERT

Identifiers

PMID32114208
PMCPMC7334059
OpenAlexW3005828731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.