Evidence map›Paper›PMID 32114151›Full record

ArticleNeuroImage2020

Connectome-based neurofeedback: A pilot study to improve sustained attention.

Dustin Scheinost, Tiffany W Hsu, Emily W Avery, Michelle Hampson, R Todd Constable, Marvin M Chun, Monica D Rosenberg

Abstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  11. Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  12. Edge-centric network control on the human brain structural network.Imaging neuroscience (Cambridge, Mass.) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA; Department of Statistics and Data Science, Yale University, New Haven, CT, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA. Electronic address: dustin.scheinost@yale.edu.
Tiffany W HsuDepartment of Psychology, Stanford University, Stanford, CA, USA.
Emily W AveryDepartment of Psychology, Yale University, New Haven, CT, USA.
Michelle HampsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
R Todd ConstableDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA; Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Marvin M ChunInterdepartmental Neuroscience Program, Yale University, New Haven, CT, USA; Department of Psychology, Yale University, New Haven, CT, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Monica D RosenbergDepartment of Psychology, Yale University, New Haven, CT, USA; Department of Psychology, University of Chicago, Chicago, IL, USA. Electronic address: mdrosenberg@uchicago.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Whole Brain Functional Connectivity Measures of AttentionR01MH108591 · NIMH · YALE UNIVERSITY · PI CHUN, MARVIN M · 2016 to 2019
$1.7M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH108591
6 · The paper itself

Abstract

Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback is a non-invasive, non-pharmacological therapeutic tool that may be useful for training behavior and alleviating clinical symptoms. Although previous work has used rt-fMRI to target brain activity in or functional connectivity between a small number of brain regions, there is growing evidence that symptoms and behavior emerge from interactions between a number of distinct brain areas. Here, we propose a new method for rt-fMRI, connectome-based neurofeedback, in which intermittent feedback is based on the strength of complex functional networks spanning hundreds of regions and thousands of functional connections. We first demonstrate the technical feasibility of calculating whole-brain functional connectivity in real-time and provide resources for implementing connectome-based neurofeedback. We next show that this approach can be used to provide accurate feedback about the strength of a previously defined connectome-based model of sustained attention, the saCPM, during task performance. Although, in our initial pilot sample, neurofeedback based on saCPM strength did not improve performance on out-of-scanner attention tasks, future work characterizing effects of network target, training duration, and amount of feedback on the efficacy of rt-fMRI can inform experimental or clinical trial designs.

Indexed as

AdultAttentionBrainConnectomeFemaleHumansMagnetic Resonance ImagingMaleNeurofeedbackPilot ProjectsAttentionConnectome-based predictive modelingFunctional connectivityNeurofeedbackReal-time fMRI

Identifiers

PMID32114151
PMCPMC7165055

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.